Comparison of multi-walled carbon nanotube and nitrogen-doped multi-walled carbon nanotube effects on lung function and airway reactivity in rats.

07:00 EST 10th November 2018 | BioPortfolio

Summary of "Comparison of multi-walled carbon nanotube and nitrogen-doped multi-walled carbon nanotube effects on lung function and airway reactivity in rats."

Incorporation of multi-wall carbon nanotubes (MWCNT) into materials has raised concerns about their potential hazards to manufacturing workers. In animal models, airway inflammation and lung fibrosis follow aspiration, instillation, and inhalation exposures to MWCNT. However, the effects of MWCNT on pulmonary function, airway reactivity and airway epithelium function following inhalation exposure has not been studied. We investigated whether inhaled MWCNT affects lung resistance (R) and dynamic compliance (C), reactivity to inhaled methacholine (MCh), epithelial regulation of airway reactivity to MCh in vitro, and airway epithelial ion transport. Male rats were exposed by whole body inhalation for 6 h to air or aerosolized MWCNT (0.5, 1 or 5 mg/m) for one or nine days. Eighteen h after 1 d exposure to 5 mg/m MWCNT, basal R was increased and basal C was decreased; changes did not persist for 7 d. Reactivity to MCh (R) was increased and C responses were decreased at 18 h, but not 7 d after exposure to 1 and 5 mg/m MWCNT. The effects of i.t.-instilled MWCNT and nitrogen-doped MWCNT (N-MWCNT) on pulmonary function and reactivity to MCh at doses comparable to deposition after inhalation of 5 mg/m at 1 d and 0.5, 1, and 5 mg/m MWCNT 9 d-exposures were compared. Both nanoparticles increased airway reactivity (R); N-MWCNT did not affect C responses. Lung function and airway reactivity are altered following a single MWCNT inhalation and generally subside over time. Given i.t., MWCNT's and N-MWCNT's effects were comparable, but N-MWCNT evoke smaller changes in C responses.


Journal Details

This article was published in the following journal.

Name: Toxicology and applied pharmacology
ISSN: 1096-0333


DeepDyve research library

PubMed Articles [11021 Associated PubMed Articles listed on BioPortfolio]

Highly selective, reusable electrochemical impedimetric DNA sensors based on carbon nanotube/polymer composite electrode without surface modification.

We fabricated a composite of multi-walled carbon nanotube and polydimethylsiloxane and utilized it as an electrode for DNA sensing using electrochemical impedance spectroscopy. Without any surface mod...

Percolation-amplified infrared sensitivity in titanium oxide-multi-walled carbon nanotube composite films.

Titanium dioxide (TiO2)-multi-walled carbon nanotube (MWCNT) thin films were prepared and studied systematically for the effects of the concentration of MWCNTs on electro-optical properties. Result sh...

Interface self-assembly preparation of multi-element doped carbon nanobowls with high electrocatalysis activity for oxygen reduction reaction.

Developing an efficient, stable and low cost oxygen reduction reaction electrocatalyst is desirable for fuel cells and metal-air batteries. Here, we have successfully prepared multi-element doped carb...

Aliovalent Fe(iii)-doped NiO microspheres for enhanced butanol gas sensing properties.

Fe-Doped NiO multi-shelled microspheres have been synthesized via a facile hydrothermal reaction. Various characterization techniques were introduced to investigate the structure and morphology of the...

Bimetallic metal-organic frameworks derived cobalt nanoparticles embedded in nitrogen-doped carbon nanotube nanopolyhedra as advanced electrocatalyst for high-performance of activated carbon air-cathode microbial fuel cell.

A new type of nitrogen-doped carbon nanotube embedded cobalt nanoparticles nanopolyhedra (Co-NCNTNP) electrocatalyst synthesized via pyrolysis bimetallic metal-organic frameworks was investigated to m...

Clinical Trials [8486 Associated Clinical Trials listed on BioPortfolio]

Rad Predictors for WON

This is a retrospective chart review study examining 1) demographic data such as age, sex, etiology of pancreatitis 2) clinical data including radiological characteristics of walled off pa...

Comparing Fully Covered, Self Expanding Metal Stent (FCSEMS) and Plastic Stents for EUS- Guided Drainage of WON

This is a multi-center, single-blinded, randomized trial comparing AXIOS FCSEMS (Fully Covered Self Expanding Metal Stent) and plastic stents for EUS (Endoscopic Ultrasound)-guided managem...

Conventional Bite Wing Radiography Versus Stationary Intraoral Tomosynthesis, a Comparison Study

A comparison of caries detection rates between conventional intraoral bitewing radiography and a stationary intraoral digital tomosynthesis (s-IOT) using a carbon nanotube X-ray source arr...

Evaluation of Efficacy and Safety of Vismed Gel Multi 0.3% Versus Vismed Multi 0.18% on Treatment of Ocular Dryness

This study is a multicentric, comparative, randomized, investigator-blinded, parallel group study to demonstrate the non-inferiority of Vismed® Gel Multi 0.3% in comparison with Vismed® ...

AXIOS Lumen Apposing Metal Stent for Walled Off Necrosis Drainage IDE Study

To demonstrate safety and effectiveness of lumen-apposing metal stents for resolution of walled off pancreatic necrosis (WONs) in patients with WONs with solid component >30%.

Medical and Biotech [MESH] Definitions

A broad category of multi-ingredient preparations that are marketed for the relief of upper respiratory symptoms resulting from the COMMON COLD; ALLERGIES; or HUMAN INFLUENZA. While the majority of these medications are available as OVER-THE-COUNTER DRUGS some of them contain ingredients that require them to be sold as PRESCRIPTION DRUGS or as BEHIND-THE COUNTER DRUGS.

Enzymes that catalyze the cleavage of a carbon-nitrogen bond by means other than hydrolysis or oxidation. Subclasses are the AMMONIA-LYASES, the AMIDINE-LYASES, the amine-lyases, and other carbon-nitrogen lyases. EC 4.3.

Enzymes that catalyze the joining of two molecules by the formation of a carbon-nitrogen bond. EC 6.3.

Enzymes that catalyze the joining of glutamine-derived ammonia and another molecule. The linkage is in the form of a carbon-nitrogen bond. EC 6.3.5.

Comparison of various psychological, sociological, or cultural factors in order to assess the similarities or diversities occurring in two or more different cultures or societies.

Quick Search


DeepDyve research library

Relevant Topic

Pulmonary relating to or associated with the lungs eg Asthma, chronic bronchitis, emphysema, COPD, Cystic Fibrosis, Influenza,  Lung Cancer, Pneumonia, Pulmonary Arterial Hypertension, Sleep Disorders etc Follow and track Lung Cancer News ...

Searches Linking to this Article