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Hypofractionated radiotherapy with concomitant boost for breast cancer: A dose escalation study.

07:00 EST 15th November 2018 | BioPortfolio

Summary of "Hypofractionated radiotherapy with concomitant boost for breast cancer: A dose escalation study."

Patients with breast cancer with pathological stage pT and at least one risk factor for local recurrence such as N1 disease, lymphovascular invasion, extensive intraductal component, close margins, non-hormone sensitive disease, grading G3 were enrolled. Patients were treated with hypofractionated RT to whole breast with a dose of 40.05 Gy in 15 fractions. The dose was escalated to the tumour bed through a daily concomitant boost technique at three dose levels: 48 Gy (3.2 Gy/die), 50.25 Gy(3.35 Gy/die) and 52.5 Gy (3.5 Gy/die). Dose escalation to a higher step was carried out if all patients of the lower dose had completed the treatment without DLT. Skin toxicity, cosmetic evaluation and quality of life was evaluated at baseline, at treatment end and at 3 and 12 months after RT end.

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Journal Details

This article was published in the following journal.

Name: The British journal of radiology
ISSN: 1748-880X
Pages: 20180169

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