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Developmental and functional characteristics of the thoracic aorta perivascular adipocyte.

07:00 EST 17th November 2018 | BioPortfolio

Summary of "Developmental and functional characteristics of the thoracic aorta perivascular adipocyte."

Thoracic aorta perivascular adipose tissue (T-PVAT) has critical roles in regulating vascular homeostasis. However, the developmental characteristics and cellular lineage of adipocyte in the T-PVAT remain unclear. We show that T-PVAT contains three long strip-shaped fat depots, anterior T-PVAT (A-T-PVAT), left lateral T-PVAT (LL-T-PVAT), and right lateral T-PVAT (RL-T-PVAT). A-T-PVAT displays a distinct transcriptional profile and developmental origin compared to the two lateral T-PVATs (L-T-PVAT). Lineage tracing studies indicate that A-T-PVAT adipocytes are primarily derived from SM22α progenitors, whereas L-T-PVAT contains both SM22α and Myf5 cells. We also show that L-T-PVAT contains more UCP1 brown adipocytes than A-T-PVAT, and L-T-PVAT exerts a greater relaxing effect on aorta than A-T-PVAT. Angiotensin II-infused hypertensive mice display greater macrophage infiltration into A-T-PVAT than L-T-PVAT. These combined results indicate that L-T-PVAT has a distinct development from A-T-PVAT with different cellular lineage, and suggest that L-T-PVAT and A-T-PVAT have different physiological and pathological functions.

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This article was published in the following journal.

Name: Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
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