Cleavage of loops 1 and 2 in skeletal muscle heavy meromyosin (HMM) leads to a decreased function.

07:00 EST 19th November 2018 | BioPortfolio

Summary of "Cleavage of loops 1 and 2 in skeletal muscle heavy meromyosin (HMM) leads to a decreased function."

The mechanical work and the actin-activated ATP kinetics in skeletal muscles are closely associated with two surface loops that are present in the myosin molecule: loop 1 and loop 2. They are located close to the ATP-loop (loop 1), and the actin binding domain (loop 2). In this study we investigated the roles of loops 1 and 2 in the regulation of the load-dependent velocity of actin sliding and ATPase activity.


Journal Details

This article was published in the following journal.

Name: Archives of biochemistry and biophysics
ISSN: 1096-0384


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