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Characterization of the partition rate of ibuprofen across the water-octanol interface and the influence of common pharmaceutical excipients.

07:00 EST 21st November 2018 | BioPortfolio

Summary of "Characterization of the partition rate of ibuprofen across the water-octanol interface and the influence of common pharmaceutical excipients."

This work reports the measurement of the partition rate of a model drug, ibuprofen, from aqueous solutions into octanol with the absence and presence of common pharmaceutical excipients including glucose, lactose, maltoheptaose, HPMC, PVP, PVP-VA, HPMCAS, sodium dodecyl sulfate, Tween 80, and sodium taurocholate at varying concentrations. This attempts to assess the kinetic aspect of IBU partitioning across the water-octanol interface by applying a mechanistic model and to characterize the interfacial resistance. A significant reduction of the Pi across the water-octanol interface was observed with extremely low concentration of the selected excipients in the aqueous media. These results reveal the presence of a surface excess of adsorbed excipients at the water-octanol interface. The retardation of the Pi of IBU was found to be sensitive to (1) the molecular weight and/or the degree of polymerization of these excipients, (2) the hydrodynamic condition of the experimental method, and (3) the pH of the aqueous media. Retardation of the Pi of IBU in the presence of excipients observed in this study is proposed by a steric obstruction mechanism through the adsorbed surface excess layer of excipients located at the water-octanol interface.

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This article was published in the following journal.

Name: Journal of pharmaceutical sciences
ISSN: 1520-6017
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