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Tissue adhesives have been developed to overcome the difficulties of conventional wound closure techniques (e.g. sutures and staples), such as the potential for collateral damage and difficulty of stopping body fluid and gas. At the same time, it provides advantages such as simpler implementation, less painful, and does not require removal. However, representative adhesives such as cyanoacrylates and fibrin glues are plagued by cytotoxicity and low adhesion. In this study, we choose instead gelatin as the backbone of adhesive, due to its biocompatibility, biodegradability, and low cost. Firstly, catechol-modified gelatin and phenol-modified gelatin were synthesized via an EDC/NHS chemistry. Then, gelatin-based adhesives were prepared via ruthenium-based photochemistry, including photo-crosslinked gelatin (PG), phenol-modified gelatin (PPG), and catechol-modified gelatin (PCG). We also compared the photo-crosslinked adhesives to the recently reported ion-crosslinked catechol-modified gelatin. Our results indicate that gelatin-based adhesives demonstrate lower swelling index, great degradability, and low cytotoxicity. This shows that gelatin-based adhesives demonstrate great potential for wound closure and healing.
This article was published in the following journal.
Name: Colloids and surfaces. B, Biointerfaces
Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary ...
Gelatin methacryloyl (acetyl) (GM(A)) is increasingly investigated for various applications in life sciences and medicine, for example, drug release or tissue engineering. Gelatin type A and type B ar...
Hydrogel microcapsules having the ability to promote cell adhesion and proliferation are a useful tool for fabricating tissue in vitro. The present study explored the effects of two anionic polysaccha...
Lightweight (LW) polypropylene (PP) meshes better adapt to host tissue, causing less fibrosis and inflammatory responses than high-density meshes. Mesh fixation using tissue adhesives (TA) that replac...
Design of functionalized biomimetic scaffolds is one of the key approaches for regenerative medicine and other biomedical applications. Development of engineered tissue should optimize organization an...
Cyanoacrylate tissue adhesives have been successfully used for wound closure. The purpose of this clinical trial is to compare cyanoacrylate tissue adhesives to polytetrafluoroethylene (PT...
This prospective, double-blind randomized controlled trial evaluates the differences in terms of efficacy and safety of gelatin based resuscitation as compared to crystalloid based resusci...
Previous work has shown that gelatin supplementation could increase collagen synthesis in humans. In this study subjects consume placebo, 5 or 15 g of gelatin with a standard amount of vit...
The purpose of the study is to show that Fibrocaps plus gelatin sponge is better than gelatin sponge alone in stopping mild to moderate bleeding in children having surgery
This randomized clinical trial evaluates the clinical performance of a new two-component self-etch universal adhesive, OptiBond XTR, when applied in non-carious Class V cervical lesions wi...
A plant genus of the family RUBIACEAE. Members contain genepin, from which geniposide is obtained for use as a crosslinking agent in ADHESIVES, and 3-caffeoyl-4-sinapoylquinic acid.
Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Substances that cause the adherence of two surfaces. They include glues (properly collagen-derived adhesives), mucilages, sticky pastes, gums, resins, or latex.
Devices used to hold tissue structures together for repair, reconstruction or to close wounds. They may consist of adsorbable or non-adsorbable, natural or synthetic materials. They include tissue adhesives, skin tape, sutures, buttons, staples, clips, screws, etc., each designed to conform to various tissue geometries.
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...