Unveiling the regulation of NKT17 cell differentiation and function.

07:00 EST 26th November 2018 | BioPortfolio

Summary of "Unveiling the regulation of NKT17 cell differentiation and function."

Invariant natural killer T cells (iNKTs) are distinct from conventional T cells. iNKT cells express a semi-invariant T cell receptor (TCR) that can specifically recognize lipid antigens presented by CD1d, an MHC class I-like antigen-presenting molecule. Currently, iNKT cells are distinguished in three functionally distinct subsets. Each subset is defined by lineage-specifying factors: T-bet shapes the fate of NKT1 subset that mainly secretes IFNγ, Gata3 specifies the NKT2 subset that produces robustly IL-4 whereas RORγt seals the differentiation of NKT17 subset that secretes IL-17. In the present review, the focus is placed on the regulation of NKT17 specification and their function.


Journal Details

This article was published in the following journal.

Name: Molecular immunology
ISSN: 1872-9142
Pages: 55-61


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