Advertisement

Topics

The effect of acute hypohydration on glycemic regulation in healthy adults: a randomized crossover trial.

07:00 EST 29th November 2018 | BioPortfolio

Summary of "The effect of acute hypohydration on glycemic regulation in healthy adults: a randomized crossover trial."

The aim of this study was to investigate the acute effect of hydration status on glycemic regulation in healthy adults and explore underlying mechanisms. In this randomized crossover trial, 16 healthy adults (8 male) underwent an oral glucose tolerance test (OGTT) when hypohydrated and rehydrated, after four days of pre-trial standardization. One day pre-OGTT, participants were dehydrated for 1-h in a heat-tent with subsequent fluid restriction (HYPO) or replacement (RE). The following day, an OGTT was performed with metabolic rate measures and pre- and post-OGTT muscle biopsies. Peripheral quantitative computer tomography thigh scans were taken pre- and post-intervention to infer changes in cell volume. HYPO (but not RE) induced 1.9±1.2% body mass loss, 2.9±2.7% cell volume reduction, and increased urinary hydration markers, serum osmolality, and plasma copeptin concentration (all p≤0.007). Fasted serum glucose (HYPO 5.10±0.42 mmol∙l; RE 5.02±0.40 mmol∙l; p=0.327) and insulin (HYPO 27.1±9.7 pmol∙L; RE 27.6±9.2 pmol∙L; p=0.809) concentrations were similar between HYPO and RE. Hydration status did not alter the serum glucose ( p=0.627) or insulin ( p=0.200) responses during the OGTT. Muscle water content was lower pre-OGTT after HYPO compared to RE (761±13 g∙kg wet weight versus 772±18 g∙kg RE), but similar post-OGTT (HYPO 779±15 g∙kg versus RE 780±20 g∙kg; time p=0.011; trial*time p = 0.055). Resting energy expenditure was similar between hydration states (stable between -1.21 and 5.94 kJ∙kg∙d; trial p=0.904). Overall, despite acute mild hypohydration increasing plasma copeptin concentrations and decreasing fasted cell volume and muscle water, we found no effect on glycemic regulation.

Affiliation

Journal Details

This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Pages:

Links

DeepDyve research library

PubMed Articles [31275 Associated PubMed Articles listed on BioPortfolio]

High-Amylose Wheat Lowers the Postprandial Glycemic Response to Bread in Healthy Adults: A Randomized Controlled Crossover Trial.

Conventional wheat-based foods contain high concentrations of readily digestible starch that commonly give these foods a high postprandial glycemic response and may contribute to the development of ty...

The Effect of Two Types of Pasta Versus White Rice on Postprandial Blood Glucose Levels in Adults with Type 1 Diabetes: A Randomized Crossover Trial.

Food choices are essential to successful glycemic control for people with diabetes. We compared the impact of three carbohydrate-rich meals on the postprandial glycemic response in adults with type 1 ...

The effect of nuts on markers of glycemic control: a systematic review and meta-analysis of randomized controlled trials.

Observational evidence suggests higher nut consumption is associated with better glycemic control; however, it is unclear if this association is causal.

The gut-brain relationship: Investigating the effect of multispecies probiotics on anxiety in a randomized placebo-controlled trial of healthy young adults.

There has been an increased interest in understanding the therapeutic effect of gut-microbiota on health, particularly in mental health. However, limited research into the connection between gut-micro...

Effect of Aerobic and Resistance Exercise on Glycemic Control in Adults With Type 1 Diabetes.

Physical exercise is recommended for individuals with type 1 diabetes, yet the effects of exercise on glycemic control are not well established. We evaluated the impact of different modes of exercise ...

Clinical Trials [22345 Associated Clinical Trials listed on BioPortfolio]

Effect of Fat Quality on Glycemic Regulation and Gut Microbiota After a Short-time Intervention in Healthy Individuals

The overall aim is to investigate effects of saturated versus polyunsaturated fat on glycemic regulation and satiety in a postprandial study with healthy individuals. The potential effects...

The Effect of Vasopressin on Glucose Regulation

Data from experimental animals and human epidemiological studies have suggested that hypohydration and/or low water intake is linked to poor glucose regulation and diabetes. The aim of thi...

Effect of Fiber on Glycemic Index

Primary objective is to investigate the effect of polydextrose on postprandial glucose concentrations in healthy adults when added to a food product. Secondary objective is to assess gast...

The Effect of Wild Blueberry Consumption on Glucose Regulation in Healthy Adults

The objective of the study is to determine how wild blueberry consumption affects glucose regulation, gastrointestinal hormones and satiety in healthy adults.

Avocado Fruit on Postprandial Markers of the Glycemic Response, Satiety/Appetite and Cardiometabolic Risk

The primary goal is to characterize the acute effects of avocado intake on glycemic and satiety/ appetite responses in relatively healthy overweight / obese adults. The secondary goal is t...

Medical and Biotech [MESH] Definitions

A quantitative value of a measured amount of a specific food that is equal to the GLYCEMIC INDEX of that food multiplied by the carbohydrate content of that food.

Works about a study where participants are assigned to a treatment, procedure, or intervention by methods that are not random. Non-randomized clinical trials are sometimes referred to as quasi-experimental clinical trials or non-equivalent control group designs.

A numerical system of measuring the rate of BLOOD GLUCOSE generation by a particular food item as compared to a reference item, such as glucose = 100. Foods with higher glycemic index numbers create greater blood sugar swings. These numbers do not correspond to calories or amounts of food intake but rather, depend on the rates of digestion and absorption of these food items.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topic

Rheumatology
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...


Searches Linking to this Article