Eye Movements in the "Morris Maze" Spatial Working Memory Task Reveal Deficits in Strategic Planning.

07:00 EST 4th December 2018 | BioPortfolio

Summary of "Eye Movements in the "Morris Maze" Spatial Working Memory Task Reveal Deficits in Strategic Planning."

Analysis of eye movements can provide insights into processes underlying performance of cognitive tasks. We recorded eye movements in healthy participants and people with idiopathic Parkinson's disease during a token foraging task based on the spatial working memory component of the widely used Cambridge Neuropsychological Test Automated Battery. Participants selected boxes (using a mouse click) to reveal hidden tokens. Tokens were never hidden under a box where one had been found before, such that memory had to be used to guide box selections. A key measure of performance in the task is between search errors (BSEs) in which a box where a token has been found is selected again. Eye movements were found to be most commonly directed toward the next box to be clicked on, but fixations also occurred at rates higher than expected by chance on boxes farther ahead or back along the search path. Looking ahead and looking back in this way was found to correlate negatively with BSEs and was significantly reduced in patients with Parkinson's disease. Refixating boxes where tokens had already been found correlated with BSEs and the severity of Parkinson's disease symptoms. It is concluded that eye movements can provide an index of cognitive planning in the task. Refixations on locations where a token has been found may also provide a sensitive indicator of visuospatial memory integrity. Eye movement measures derived from the spatial working memory task may prove useful in the assessment of executive functions as well as neurological and psychiatric diseases in the future.


Journal Details

This article was published in the following journal.

Name: Journal of cognitive neuroscience
ISSN: 1530-8898
Pages: 1-13


DeepDyve research library

PubMed Articles [12261 Associated PubMed Articles listed on BioPortfolio]

Joint attention is intact even when visuospatial working memory is occupied.

The gaze of another modulates and shifts an observer's spatial attention toward this gaze direction. This phenomenon is termed joint attention. Although previous studies found joint attention was indu...

The Barnes Maze Task Reveals Specific Impairment of Spatial Learning Strategy in the Intrahippocampal Kainic Acid Model for Temporal Lobe Epilepsy.

Temporal lobe epilepsy (TLE) is an acquired form of focal epilepsy, in which patients not only suffer from unprovoked, devastating seizures, but also from severe comorbidities, such as cognitive dysfu...

Information Transmission in HPC-PFC Network for Spatial Working Memory in Rat.

Spatial working memory is a short-term system for the temporary holding and manipulation of spatial information. Evidence shows that the hippocampus (HPC) and prefrontal cortex (PFC) play important ro...

Assessment of spatial learning and memory in the Barnes maze task in rodents-methodological consideration.

Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed ...

Optogenetic suppression of the Nucleus Reuniens selectively impairs encoding during spatial working memory.

The nucleus reuniens (Re) of the ventral midline thalamus is known to be a critical anatomical link between the hippocampus (HPC) and the medial prefrontal cortex (mPFC). Consistent with this anatomic...

Clinical Trials [3404 Associated Clinical Trials listed on BioPortfolio]

Gestural Short Term and Working Memory Task

According to the working memory model, which accounts for the organisation of working memory, the processing of non-meaningful gestures is not clear. Some authors suggest that working memo...

Augmentation of Working Memory Training With Transcranial Direct Current Stimulation in Patients With Schizophrenia

Cognitive impairment is a core symptom of schizophrenia and is in a large part responsible for the poor psychosocial outcome of the disorder. The use of non-invasive brain stimulation tech...

Study To Assess Differential Sensitivity Of 2 Spatial Working Memory Tests In Schizophrenics Treated With Risperidone

To assess the effect of risperidone 2 mg daily (QD) on the differential sensitivity of 2 spatial working memory tests (the GMLT and MDR) in non-agitated, drug-naive patients suffering from...

Spatial Cognitive Training

This study is designed to see if doing regular training on a spatial imagery task leads to improvements in the ability to do the trained spatial imagery task and in the ability to get arou...

Investigation of Oscillations Underlying Human Cognitive and Affective Processing Using Intracranial EEG

Purpose: To investigate the electrophysiological correlates of human cognition and affective processing. Participants: Drug-resistant epilepsy patients undergoing epilepsy surgery cortical...

Medical and Biotech [MESH] Definitions

Memory related to spatial information.

The observation and analysis of movements in a task with an emphasis on the amount of time required to perform the task.

Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed)

Methods used to take into account and incorporate spatial autocorrelation and regional variation into regression analysis models of data that has spatial dependency, and also to provide information on the spatial relationships among the variables.

Measures of spatial cognition and memory.

Quick Search


DeepDyve research library

Relevant Topics

Parkinson's Disease
Parkinson's is a progressive neurological condition, affecting one person in every 500, 95% of which are over 40. It is caused by degeneration of more than 70% of the substantia nigra, which depletes the dopamine (the neurotransmitter involved in pro...

Psychiatry is the study of mental disorders and their diagnosis, management and prevention.  Conditions include schizophrenia, severe depression and panic disorders among others. There are pharmaceutical treatments as well as other therapies to help...

Searches Linking to this Article