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A mulberry leaf polysaccharide (MLP-1) was prepared and partially characterised, and its anti-renal-fibrosis effects were investigated in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats. MLP-1, with a molecular weight of 2,792,624 Da, consisted of arabinose, glucose, xylose, rhamnose, and mannose in a molar ratio of 1:1.13:2.35:6.74:8.85. Intraperitoneal injection of MLP-1 (2 mL; 0.2-0.4 g/mL) daily for 8 weeks significantly decreased serum insulin, fasting blood glucose, and 24 h urinary albumin, as well as urine protein and connective tissue growth factors, of STZ-induced DN rats. All these results indicated that MLP-1 can effectively inhibit renal fibrosis and potentially treat DN.
This article was published in the following journal.
Name: International journal of biological macromolecules
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Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.
Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.
Irreversible FIBROSIS of the submucosal tissue of the MOUTH.
Polysaccharides found in bacteria and especially bacterial capsules. (Dorland, 28th ed)
The amount of PLASMA that perfuses the KIDNEYS per unit time, approximately 10% greater than effective renal plasma flow (RENAL PLASMA FLOW, EFFECTIVE). It should be differentiated from the RENAL BLOOD FLOW; (RBF), which refers to the total volume of BLOOD flowing through the renal vasculature, while the renal plasma flow refers to the rate of plasma flow (RPF).
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