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Sometimes new ideas come from old places. Complement's central role in lupus pathogenesis has been known for years, and a reduction in C3 and C4 levels is one of the strongest biomarkers for increased lupus disease activity. However, every rheumatologist knows that some patients with no symptoms of active lupus will present with low complement levels, whereas some patients with aggressive disease have levels that never budge from the "normal" range. How can we better utilize the biomarkers associated with the complement system to guide therapy in lupus - both to predict lupus flares so that damage from unwanted inflammation can be prevented and to allow withdrawal of therapy after inflammation has resolved so as to minimize harm from toxic immunosuppressants? This article is protected by copyright. All rights reserved.
This article was published in the following journal.
Name: Arthritis & rheumatology (Hoboken, N.J.)
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A form of lupus erythematosus in which the skin may be the only organ involved or in which skin involvement precedes the spread into other body systems. It has been classified into three forms - acute (= LUPUS ERYTHEMATOSUS, SYSTEMIC with skin lesions), subacute, and chronic (= LUPUS ERYTHEMATOSUS, DISCOID).
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A factor associated with the well-being of living organisms that is used as a measure of environmental change and or influence. For example, aldehyde dehydrogenase expression in earthworm tissue is used as an indication of heavy metal pollution in soils. Distinguish from BIOMARKERS.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.
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