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Better Biomarkers for Lupus Disease Activity - Tools for Treating to Target.

07:00 EST 7th December 2018 | BioPortfolio

Summary of "Better Biomarkers for Lupus Disease Activity - Tools for Treating to Target."

Sometimes new ideas come from old places. Complement's central role in lupus pathogenesis has been known for years, and a reduction in C3 and C4 levels is one of the strongest biomarkers for increased lupus disease activity. However, every rheumatologist knows that some patients with no symptoms of active lupus will present with low complement levels, whereas some patients with aggressive disease have levels that never budge from the "normal" range. How can we better utilize the biomarkers associated with the complement system to guide therapy in lupus - both to predict lupus flares so that damage from unwanted inflammation can be prevented and to allow withdrawal of therapy after inflammation has resolved so as to minimize harm from toxic immunosuppressants? This article is protected by copyright. All rights reserved.

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Name: Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
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