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Aging is associated with decreased lung function and an increased incidence of lung infections. Several studies have suggested that long-term calorie restriction (CR) promotes health and longevity and results in the reduced risk of several diseases. The effect of CR is thought to be through improving the function of tissue stem cells. Stem cell function is known to decline with aging. In this study, we examined the effects of aging on lung epithelial and stem cells, and the effect of CR on young and old lungs. We found that aging results in a decrease in tracheal basal stem cells. CR induced an increase in basal stem cells in both young and old mice. In addition, aging induced lung inflammation, and CR tended to reduce baseline lung inflammatory cell infiltration in young mice, and significantly reduced aging-induced lung inflammation. Furthermore, aging reduced the number and function of mitochondria in lung and increased level of mitochondrial ROS. CR increased the number and function of mitochondria both in young and old mice. Moreover, aging reduced lung stem cell colony forming efficiency (CFE), and CR increased the CFE in both young and old mice. Finally, CR improved epithelial cell survival in injured lungs of young mice. In conclusion, aging causes several structural and functional changes/impairments in lung epithelial cells. CR induces several potentially beneficial changes in lung epithelial cells, even when it is initiated at an older age, including reversal of some aging-induced changes.
This article was published in the following journal.
Name: Journal of tissue engineering and regenerative medicine
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PLURIPOTENT STEM CELLS derived from the BLASTOCYST INNER CELL MASS of day 3.5 mouse embryos.
Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.
Progenitor stem cells found in the testicles.
Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)
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