Paired versus two-group experimental design for rheological studies of vocal fold tissues.

07:00 EST 29th November 2018 | BioPortfolio

Summary of "Paired versus two-group experimental design for rheological studies of vocal fold tissues."

Vibratory function of the vocal folds is largely determined by the rheological properties or viscoelastic shear properties of the vocal fold lamina propria. To date, investigation of the sample size estimation and statistical experimental design for vocal fold rheological studies is nonexistent. The current work provides the closed-form sample size formulas for two major study designs (i.e. paired and two-group designs) in vocal fold research. Our results demonstrated that the paired design could greatly increase the statistical power compared to the two-group design. By comparing the variance of estimated treatment effect, this study also confirms that ignoring within-subject and within-vocal fold correlations during rheological data analysis will likely increase type I errors. Finally, viscoelastic shear properties of intact and scarred rabbit vocal fold lamina propria were measured and used to illustrate theoretical findings in a realistic scenario and project sample size requirement for future studies.


Journal Details

This article was published in the following journal.

Name: Journal of biomechanics
ISSN: 1873-2380


DeepDyve research library

PubMed Articles [31258 Associated PubMed Articles listed on BioPortfolio]

The Effectiveness of Vocal Hygiene Education for Decreasing At-Risk Vocal Behaviors in Vocal Performers.

This study examined the knowledge gained and behavioral changes made by vocal performers after attending a vocal hygiene education program. A single-group, pretest-posttest research design was utilize...

The Effectiveness of Hypnosis Intervention in Alleviating Postpartum Psychological Symptoms.

Psychological symptoms, particularly postpartum depression, may impair women's well-being after childbirth. Mind-body treatments such as hypnosis are available to help prepare women to maintain or imp...

Analysis of CO₂ laser and conventional laryngomicrosurgery treatments for vocal cord cyst: an evaluation of short-term voice acoustics outcomes.

To compare the short-term outcomes of CO₂ laser and conventional laryngeal microsurgery for vocal cord cyst. Patients with vocal cord cyst were divided randomly into two groups. One group was treat...

Increasing nursing students' knowledge of evidence-based hand-hygiene: A quasi-experimental study.

Aim of study was to evaluate the effects of a multi-component intervention on nursing students' knowledge of evidence-based hand-hygiene. A quasi-experimental design was used. Nursing students (N =...

Acting in action: Prosodic analysis of character portrayal during acting.

During the process of acting, actors have to embody the characters that they are portraying by changing their vocal and gestural features to match standard conceptions of the characters. In this exper...

Clinical Trials [13463 Associated Clinical Trials listed on BioPortfolio]

Immediate Effect Analysis of Vocal Techniques

The objective of this clinical and experimental study was to verify the immediate effect of vocal techniques: vibration, nasal sound and articulation in women without vocal complaints.

Assessment of Rheological Parameters of Human Sputum.

This is a proof of concept study. The aim of this study is to assess a device measuring rheological properties of human sputum of four populations : - 10 patients with Broncho Chronic ...

Controlled Phonation and Vocal Rest Programs After Acute Vocal Exertion in Healthy Adults

The proposed research will investigate the most effective strategy to reduce vocal exertion reported by speakers in noisy environments. Repeated vocal exertion can lead to voice problems a...

Characterization of the Autofluorescence of Healthy and Pathological Tissues of Vocal Cords

The aim of this clinical trial is to provide information about autofluorescence of pathological versus healthy vocal folds tissues. Experimentations are performed on vocal folds biopsies ...

High-intensity Group Vocal Exercise to Improve Laryngeal Function in Patients With Parkinson Disease

The overall goal of this T2 translational research project is to pilot an interdisciplinary high-intensity group singing program to improve speech and swallowing in patients with Parkinson...

Medical and Biotech [MESH] Definitions

Groups that serve as a standard for comparison in experimental studies. They are similar in relevant characteristics to the experimental group but do not receive the experimental intervention.

Artificial substitutes for body parts and materials inserted into organisms during experimental studies.

A pair of cone-shaped elastic mucous membrane projecting from the laryngeal wall and forming a narrow slit between them. Each contains a thickened free edge (vocal ligament) extending from the THYROID CARTILAGE to the ARYTENOID CARTILAGE, and a VOCAL MUSCLE that shortens or relaxes the vocal cord to control sound production.

An approach, process, or methodology which emphasizes credible evidence and the best available scientific knowledge, judiciously integrated to achieve the best possible outcomes in structural design. For example, the design of a new OUTPATIENT CLINIC might incorporate a review of published research on outpatient clinic design, decisions on similar past projects, along with interviews with staff and consumers.

The process of producing vocal sounds by means of VOCAL CORDS vibrating in an expiratory blast of air.

Quick Search


DeepDyve research library

Searches Linking to this Article