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Continuous Drug Delivery Aiming Continuous Dopaminergic Stimulation in Parkinson's Disease.

07:00 EST 1st January 2018 | BioPortfolio

Summary of "Continuous Drug Delivery Aiming Continuous Dopaminergic Stimulation in Parkinson's Disease."

Continuous dopaminergic stimulation in Parkinson's disease (PD) has several advantages over pulsatile, non-continuous, stimulation. These therapies currently consist of pump-based and transcutaneous therapies and are based on a more constant delivery of the dopaminergic drug resulting in continuous dopaminergic stimulation and a more stable treatment effect. Several clinical and experimental observations have shown that continuous stimulation of dopaminergic receptors induces fewer complications, such as dyskinesia, compared to pulsatile stimulation. Currently available non-oral pharmacological continuous therapies in PD include the transdermal Rotigotine (RTG) patch, infusion therapies with Apomorphine and Intrajejunal Levodopa (IJLI) and the Rivastigmine patch. Here we aim to provide a concise review of these current therapies and discuss ongoing and future developments of continuous non-oral pharmacological dopaminergic therapies in PD.

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Journal Details

This article was published in the following journal.

Name: Journal of Parkinson's disease
ISSN: 1877-718X
Pages: S65-S72

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