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Insulin-like growth factor-I is inversely associated with liver fibrotic markers in patients with type 2 diabetes mellitus.

07:00 EST 28th December 2018 | BioPortfolio

Summary of "Insulin-like growth factor-I is inversely associated with liver fibrotic markers in patients with type 2 diabetes mellitus."

Insulin-like growth factor-I regulates mitochondrial function, oxidative stress, inflammation, stellate cells, and insulin sensitivity in the liver, and it might be associated with liver fibrosis from non-alcoholic steatohepatitis (NASH). On the other hand, type 2 diabetes mellitus (T2DM) is closely associated with the progression from non-alcoholic fatty liver to NASH and cirrhosis, so careful evaluation of liver fibrosis is required in patients with T2DM. Therefore, we examined the relationship between insulin-like growth factor-I and liver fibrosis markers in type 2 diabetes patients without obvious alcoholic consumption and determined whether insulin-like growth factor-I is associated with fibrosis of non-alcoholic fatty liver disease.

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This article was published in the following journal.

Name: Journal of diabetes investigation
ISSN: 2040-1124
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Medical and Biotech [MESH] Definitions

A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.

A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.

One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.

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