A chicken bioreactor for efficient production of functional cytokines.

07:00 EST 29th December 2018 | BioPortfolio

Summary of "A chicken bioreactor for efficient production of functional cytokines."

The global market for protein drugs has the highest compound annual growth rate of any pharmaceutical class but their availability, especially outside of the US market, is compromised by the high cost of manufacture and validation compared to traditional chemical drugs. Improvements in transgenic technologies allow valuable proteins to be produced by genetically-modified animals; several therapeutic proteins from such animal bioreactors are already on the market after successful clinical trials and regulatory approval. Chickens have lagged behind mammals in bioreactor development, despite a number of potential advantages, due to the historic difficulty in producing transgenic birds, but the production of therapeutic proteins in egg white of transgenic chickens would substantially lower costs across the entire production cycle compared to traditional cell culture-based production systems. This could lead to more affordable treatments and wider markets, including in developing countries and for animal health applications.


Journal Details

This article was published in the following journal.

Name: BMC biotechnology
ISSN: 1472-6750
Pages: 82


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