Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC).

07:00 EST 2nd January 2019 | BioPortfolio

Summary of "Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)."

A preloaded resin consisting of a thalidomide moiety and an ethylene-oxy linker allows the simple and fast formation of PROTACs. The feasibility of the procedure was illustrated by conjugating different protein kinase inhibitors. The biological functionality of an ibrutinib-like conjugate was then confirmed by a cellular experiment.


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This article was published in the following journal.

Name: Chemical communications (Cambridge, England)
ISSN: 1364-548X


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