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lncRNA H19 prevents endothelial-mesenchymal transition in diabetic retinopathy.

07:00 EST 5th January 2019 | BioPortfolio

Summary of "lncRNA H19 prevents endothelial-mesenchymal transition in diabetic retinopathy."

The pathophysiology of diabetic retinopathy is linked to hyperglycaemia and its effect on retinal microvascular tissues. The resulting endothelial injury changes the endothelial cell phenotype to acquire mesenchymal properties (i.e. endothelial-mesenchymal transition [EndMT]). Such changes can be regulated by epigenetic mechanisms, including long non-coding RNAs (lncRNAs). lncRNA H19 may influence EndMT through TGF-β. We investigated the role of H19 in regulating EndMT during diabetic retinopathy.

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This article was published in the following journal.

Name: Diabetologia
ISSN: 1432-0428
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