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Three-Fraction Accelerated Partial Breast Irradiation (Apbi) Delivered With Brachytherapy Applicators Is Feasible And Safe : First Results From The Triumph-T Trial.

07:00 EST 3rd January 2019 | BioPortfolio

Summary of "Three-Fraction Accelerated Partial Breast Irradiation (Apbi) Delivered With Brachytherapy Applicators Is Feasible And Safe : First Results From The Triumph-T Trial."

Shorter courses of APBI delivered as single-fraction intraoperative therapy are now offered as an alternative to 4-6 weeks of whole breast irradiation after lumpectomy; however, there are potential patient selection, dosimetric, target volume definition, radiobiological, and logistical shortcomings of this approach. We designed a prospective phase II multi-institution clinical trial to study 2 or 3 day APBI delivered with brachytherapy applicators.

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This article was published in the following journal.

Name: International journal of radiation oncology, biology, physics
ISSN: 1879-355X
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Medical and Biotech [MESH] Definitions

Irradiation of one half or both halves of the body in the treatment of disseminated cancer or widespread metastases. It is used to treat diffuse metastases in one session as opposed to multiple fields over an extended period. The more frequent treatment modalities are upper hemibody irradiation (UHBI) or lower hemibody irradiation (LHBI). Less common is mid-body irradiation (MBI). In the treatment of both halves of the body sequentially, hemibody irradiation permits radiotherapy of the whole body with larger doses of radiation than could be accomplished with WHOLE-BODY IRRADIATION. It is sometimes called "systemic" hemibody irradiation with reference to its use in widespread cancer or metastases. (P. Rubin et al. Cancer, Vol 55, p2210, 1985)

A fluid-filled closed cavity or sac that is lined by an EPITHELIUM and found in the BREAST. It may appear as a single large cyst in one breast, multifocal, or bilateral in FIBROCYSTIC BREAST DISEASE.

A common and benign breast disease characterized by varying degree of fibrocystic changes in the breast tissue. There are three major patterns of morphological changes, including FIBROSIS, formation of CYSTS, and proliferation of glandular tissue (adenosis). The fibrocystic breast has a dense irregular, lumpy, bumpy consistency.

Abnormal accumulation of lymph in the arm, shoulder and breast area associated with surgical or radiation breast cancer treatments (e.g., MASTECTOMY).

External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.

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