The link between maternal obesity and offspring neurobehavior: a systematic review of animal experiments.

07:00 EST 3rd January 2019 | BioPortfolio

Summary of "The link between maternal obesity and offspring neurobehavior: a systematic review of animal experiments."

Maternal obesity in pregnancy is associated with neurobehavioral problems in the offspring. Establishing causality has been challenging in existing human studies, due to confounding by genetic and postnatal environment. Animal experiments can improve our understanding of this association. This systematic review examined the effects of maternal obesity in pregnancy on offspring neurobehavior in animal models. We included 26 studies (1047 offspring animals). Meta-analyses showed that offspring of obese mothers displayed higher levels of locomotor activity (standardized mean difference (SMD) .34 [.10;.58]) and anxiety behavior (SMD .47 [.16;.79]) than offspring of lean mothers, but similar memory abilities (SMD -.06 [-.52;.39]). Meta-analysis of learning abilities was not sensible due to heterogeneity. Although the evidence was heterogeneous and the quality of the included studies generally unclear, this systematic review of animal studies indicates an effect of maternal obesity on increased offspring locomotor activity and anxiety, but not on offspring memory performance. These findings may be important from a public health perspective since obesity is rapidly increasing worldwide, and warrant further research.


Journal Details

This article was published in the following journal.

Name: Neuroscience and biobehavioral reviews
ISSN: 1873-7528


DeepDyve research library

PubMed Articles [18469 Associated PubMed Articles listed on BioPortfolio]

Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies.

Obesity before and during pregnancy leads to reduced offspring cardiometabolic health. Here, we systematically reviewed animal experimental evidence of maternal obesity before and during pregnancy and...

Metabolic analysis of adipose tissues in a rodent model of pre-pregnancy maternal obesity combined with offsprings on high-carbohydrate diet.

Maternal obesity is associated with adverse effects on the health of offsprings. Consumption of a high-carbohydrate (HC) diet has been found to promote abnormal fatty acid metabolism in adipose tissue...

The Relationship between Maternal Global Nutrient Restriction during Pregnancy and Offspring Kidney Structure and Function:A Systematic Review of Animal studies.

Maternal under-nutrition during pregnancy is prevalent across the globe, and the origins of many chronic diseases can be traced back to in utero conditions. This systematic review considers the curren...

A maternal high-fat diet may accelerate adipo-immunologic aging in offspring.

Maternal obesity and improper nutrition predispose offspring to chronic metabolic diseases. Although the frequency of these diseases increases with aging, the effect of a maternal high-fat diet on age...

The impact of maternal obesity in pregnancy on placental glucocorticoid and macronutrient transport and metabolism.

Maternal obesity is the most common metabolic disturbance in pregnancy affecting >1 in 5 women in some countries. Babies born to obese women are heavier with more adiposity at birth, and are vulnerabl...

Clinical Trials [6327 Associated Clinical Trials listed on BioPortfolio]

Effects of Maternal Obesity on Offspring Brain Development

The goal of this study is to see if there are negative effects of maternal obesity during pregnancy on offspring's brain development.

Breastfeeding and Obesity on Offspring Body Composition

The purpose of this study is to explore the effect maternal obesity and breastfeeding play on infant body composition. The investigators hypothesize in the first 6 months of life breast f...

Lifestyle Intervention in Preparation for Pregnancy (LIPP)

The objective of this proposal is to break the vicious cycle of obesity/metabolic dysfunction during pregnancy. Lifestyle interventions in obese women during pregnancy have had limited suc...

Epidural Labor Analgesia and Infant Neurobehavior

Infant neurobehavior alteration is predictor of later intelligence development. Many factors would influence or are associated with infant neurobehavior, of which exist or appear during pe...

Maternal Lipids and Offspring Adiposity at 5-7 Years

This study investigates the associations between measured maternal lipids (Total cholesterol, LDL-cholesterol , triglycerides and high-density lipoprotein cholesterol) at 28 weeks' gestati...

Medical and Biotech [MESH] Definitions

Exposure of the female parent, human or animal, to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals that may affect offspring. It includes pre-conception maternal exposure.

Prolonged separation of the offspring from the mother.

Review of the medical necessity of hospital or other health facility admissions, upon or within a short time following an admission, and periodic review of services provided during the course of treatment.

Multi-step systematic review process used for improving safety by investigation of incidents to find what happened, why it happened, and to determine what can be done to prevent it from happening again.

Transmission of genetic characters, qualities, and traits, solely from maternal extra-nuclear elements such as MITOCHONDRIAL DNA or MATERNAL MESSENGER RNA.

Quick Search


DeepDyve research library

Relevant Topics

Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...

Diabetes Diabetes Endocrine Disorders Obesity Oxycontin Renal Disease Thyroid Disorders Endocrinology is the study of the endocrine glands and the hormones that they secrete (Oxford Medical Dictionary). There are several g...

Searches Linking to this Article