Double Infection With and in an HIV Patient Controlled With High Doses of Amphotericin B.
Summary of "Double Infection With and in an HIV Patient Controlled With High Doses of Amphotericin B."
We present a unique case of disseminated Leishmaniasis in an HIV patient. Two different species were identified by genomic sequencing in both bone marrow and skin. The infection could be suppressed but not cured, despite a high dose of amphotericin B of nearly 65 g over more than 6 years.
Affiliation
Journal Details
This article was published in the following journal.
Name: Open forum infectious diseases
ISSN: 2328-8957
Pages: ofy323
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/30619911
- DOI: http://dx.doi.org/10.1093/ofid/ofy323
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Medical and Biotech [MESH] Definitions
Analgesia, Patient-controlled
Relief of PAIN, without loss of CONSCIOUSNESS, through ANALGESIC AGENTS administered by the patients. It has been used successfully to control POSTOPERATIVE PAIN, during OBSTETRIC LABOR, after BURNS, and in TERMINAL CARE. The choice of agent, dose, and lockout interval greatly influence effectiveness. The potential for overdose can be minimized by combining small bolus doses with a mandatory interval between successive doses (lockout interval).
Patient Isolation
The segregation of patients with communicable or other diseases for a specified time. Isolation may be strict, in which movement and social contacts are limited; modified, where an effort to control specified aspects of care is made in order to prevent cross infection; or reverse, where the patient is secluded in a controlled or germ-free environment in order to protect him or her from cross infection.
Hormesis
Biphasic dose responses of cells or organisms (including microorganisms) to an exogenous or intrinsic factor, in which the factor induces stimulatory or beneficial effects at low doses and inhibitory or adverse effects at high doses.
Tachyphylaxis
Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. In immunology, it is the rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. (Dorland, 28th ed)
Cross Infection
Any infection which a patient contracts in a health-care institution.
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