Advertisement

Topics

Store-operated calcium entry in disease: Beyond STIM/Orai expression levels.

07:00 EST 7th January 2019 | BioPortfolio

Summary of "Store-operated calcium entry in disease: Beyond STIM/Orai expression levels."

Precise intracellular calcium signaling is crucial to numerous cellular functions. In non-excitable cells, store-operated calcium entry (SOCE) is a key step in the generation of intracellular calcium signals. Tight regulation of SOCE is important, and dysregulation is involved in several pathophysiological cellular malfunctions. The current underlying SOCE, calcium release-activated calcium current (I), was first discovered almost three decades ago. Since its discovery, the molecular components of I, Orai1 and stromal interaction molecule 1 (STIM1), have been extensively investigated. Several regulatory mechanisms and proteins contribute to alterations in SOCE and cellular malfunctions in cancer, immune and neurodegenerative diseases, inflammation, and neuronal disorders. This review summarizes these regulatory mechanisms, including glycosylation, pH sensing, and the regulatory proteins golli, α-SNAP, SARAF, ORMDL3, CRACR2 A, and TRPM4 channels.

Affiliation

Journal Details

This article was published in the following journal.

Name: Seminars in cell & developmental biology
ISSN: 1096-3634
Pages:

Links

DeepDyve research library

PubMed Articles [17743 Associated PubMed Articles listed on BioPortfolio]

Numbers count: How STIM and Orai stoichiometry affect store-operated calcium entry.

Substantial progress has been made in the past several years in establishing the stoichiometries of STIM and Orai proteins and understanding their influence on store-operated calcium entry. Depletion ...

CRAC channel regulation of innate immune cells in health and disease.

Calcium is a major intracellular signaling messenger in innate immune cells. Similar to other immune cell subsets, the majority of calcium entry into innate immune cells is induced by cell surface rec...

Structural features of STIM and Orai underlying store-operated calcium entry.

Store-operated calcium entry (SOCE) through Orai channels is triggered by receptor-stimulated depletion of Ca from the ER. Orai1 is unique in terms of its activation mechanism, biophysical properties,...

IP receptors and store-operated Ca entry: a license to fill.

Inositol 1,4,5-trisphosphate receptors (IPRs) are widely expressed intracellular Ca channels that evoke large local increases in cytosolic Ca concentration. By depleting the ER of Ca, IPRs also activa...

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling and In Vivo Proof-of-Concept Efficacy in Acute Pancreatitis.

In recent years, channels that mediate Store-Operated Calcium Entry (SOCE, i.e. the ability of cells to sense a decrease in endoplasmic reticulum luminal calcium and induce calcium entry across the pl...

Clinical Trials [5138 Associated Clinical Trials listed on BioPortfolio]

Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium ch...

Effects of Neuro-Stim System on Pain, Sleep, and Opioid Use

The purpose of this study is to evaluate the ability of Neuro-Stim System, a non-pharmacologic alternative for pain management, to reduce pain and treat insomnia. Neuro-Stim System uses el...

Calcium and Phosphorus Balance and Calcium Kinetics in Patients With Stage 3/4 Chronic Kidney Disease

The purpose of this study is to gain a better understanding of calcium absorption and metabolism in patients with Chronic Kidney Disease (CKD) using calcium balance and kinetic methods.

Effectiveness of CES on Emotional and Cellular Wellbeing

The investigators aim to use a CES (cranial electrotherapy stimulation) intervention to improve emotional well-being by reducing symptoms of anxiety and depression and to assess for change...

Bone Density in Children With IBD Treated With Amorphous Calcium or Commercial Crystalline Calcium

Patients diagnosed with, or in risk of osteoporosis regularly take calcium dietary supplements, although their contribution to BMD maintenance, prevention of bone loss or reduction of the ...

Medical and Biotech [MESH] Definitions

A family of structurally related neurotoxic peptides from mollusk venom that inhibit voltage-activated entry of calcium into the presynaptic membrane. They selectively inhibit N-, P-, and Q-type calcium channels.

Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.

A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.

Intracellular signaling peptides and proteins that bind to CALCIUM. They undergo allosteric changes when bound to CALCIUM that affects their interaction with other signal-transducing molecules. They differ from CALCIUM-SENSING RECEPTORS which sense extracellular calcium levels.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topics

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...


Searches Linking to this Article