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NMDA Receptors potentiate activity-dependent dendritic release of neuropeptides from hypothalamic neurons.

07:00 EST 10th January 2019 | BioPortfolio

Summary of "NMDA Receptors potentiate activity-dependent dendritic release of neuropeptides from hypothalamic neurons."

Using "sniffer" cell biosensors, we evaluated the effects of specific firing patterns and frequencies on activity-dependent somatodendritic release of VP from PVN neurones. Somatodendritic release of VP was rarely observed during continuous firing but was strengthened by clustered activity. Moreover, release evoked at any given frequency was robustly potentiated by NMDAR-mediated firing. Differently from axonal release, NMDAR activation was necessary for somatodendritic release to occur at physiological firing frequencies, acting thus as a gating mechanism by which activity-dependent release from these two neuroneal compartments could be independently regulated. The NMDAR-mediated potentiation was independent of a specific firing pattern and was not accompanied by increased spike broadening, but correlated with higher dendritic Ca levels. Our studies provide fundamental novel information regarding stimulus-secretion coupling at somatodendritic compartments, and shed light into mechanisms by which activity-dependent release of neuronal signals from axonal terminals and dendrites could be regulated in a spatially compartmentalized manner.

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This article was published in the following journal.

Name: The Journal of physiology
ISSN: 1469-7793
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