Prenatal exposure to bisphenol A analogues on female reproductive functions in mice.

07:00 EST 10th January 2019 | BioPortfolio

Summary of "Prenatal exposure to bisphenol A analogues on female reproductive functions in mice."

This study was performed to examine whether prenatal exposure to bisphenol (BP) A analogues, BPE and BPS, negatively impacts female reproductive functions and follicular development using mice as a model. CD-1 mice were orally exposed to control treatment (corn oil), BPA, BPE or BPS (0.5, 20 or 50 µg/kg/day) from gestational day 11 (the presence of vaginal plug = 1) to birth. Exposure to BPA, BPE and BPS accelerated the onset of puberty and exhibited abnormal estrous cyclicity, especially with lower doses. Females exposed to BPA, BPE and BPS exhibited mating difficulties starting at 6 months of age. By 9 months, mice exhibited various fertility problems including reduced pregnancy rate, parturition issues, and increased dead pups at birth. Furthermore, the levels of serum testosterone were elevated by BPE or BPS exposure at the age of 9 months, whereas estrogen levels were not affected. On the other hand, the dysregulated expression of steroidogenic enzymes was observed in the ovary at 3, 6 or 9 months of age by BPE or BPS exposure. When we examined neonatal ovary on postnatal day 4, BPA, BPE and BPS exposure inhibited germ cell nest breakdown and reduced numbers of primary and secondary follicles. These results suggest that prenatal exposure to BPA analogues, BPE and BPS, have effects on fertility in later reproductive life probably due to the disruption of early folliculogenesis.


Journal Details

This article was published in the following journal.

Name: Toxicological sciences : an official journal of the Society of Toxicology
ISSN: 1096-0929


DeepDyve research library

PubMed Articles [20506 Associated PubMed Articles listed on BioPortfolio]

Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice.

Continued efforts to phase out bisphenol A (BPA) from consumer products have been met with the challenges of finding safer alternatives.

Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats: A focus on the possible hormonal mode of action.

Bisphenol A an estrogen-mimic endocrine disrupting chemical, used to manufacture polycarbonate plastics and epoxy resins with toxic effects for male reproduction. Due to its toxicity, industries have ...

Occurrence and exposure assessment of bisphenol analogues in source water and drinking water in China.

Bisphenol analogues (BPs) are widely used in the production of epoxy resins and polycarbonate plastics. In recent years, the demand and production capacity of BPs are growing rapidly in China. However...

The potential reproductive toxicity of tannery effluent to the estrous cycle and ovarian follicular dynamics of female Swiss mice.

Although the toxic effects of tannery effluent (TE) on tanning-industry workers have been reported in many studies, its effects on females' reproductive system are unknown. We aimed at evaluating the ...

Reproductive and developmental F1 toxicity following exposure of pubescent F0 male mice to bisphenol A alone and in a combination with X-rays irradiation.

Exposure to environmental toxicants may affect reproduction and development of subsequent generations. This study was aimed at determining the male-mediated F1 effects induced following 8-weeks of sub...

Clinical Trials [6036 Associated Clinical Trials listed on BioPortfolio]

Kinetic Time Courses of Bisphenol-S in Volunteers

The time course of bisphenol S in plasma and urine will be monitored in female adults exposed to a single oral and dermal dose of bisphenol-S. Six female will be recruited. Blood and urine...

Environment and Reproductive Health

The purpose of the study is to investigate the relationship between environmental agents and reproductive health. Environmental agents of interest include exposure to chemicals such as pol...

Intervention to Reduce Bisphenol A Exposure in Women

The purpose of this study is to determine whether a 3-week intervention reduces urinary Bisphenol A (BPA) in women with obesity

Prenatal PCB Exposure

This project is designed to investigate the association between prenatal exposure to environmental contaminants on cognitive development of school-age children

Composites and Urinary Bisphenol-A Study

The Composites and Urinary Bisphenol-A Study (CUBS) is a clinical study of dental composite for its effects on urinary bisphenol-A levels. The study will enroll approximately 139 children ...

Medical and Biotech [MESH] Definitions

Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).

MYCOBACTERIUM infections of the female reproductive tract (GENITALIA, FEMALE).

Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).

Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE).

The totality of characteristics of reproductive structure, functions, PHENOTYPE, and GENOTYPE, differentiating the MALE from the FEMALE organism.

Quick Search


DeepDyve research library

Relevant Topics

Benign Prostatic Hyperplasia (BPH)
An enlarged prostate (benign prostatic enlargement (BPE) or benign prostatic hyperplasia (BPH)) is common in men after the age of about 50. Having an enlarged prostate does not mean you have cancer. In some cases, an enlarged prostate can cause the ...

Fertility is the ability of a couple to conceive, but can related to specifically the man or woman. Various reasons can cause a couple to be infertile, and due to the strong desire of these patients to have <!--LGfEGNT2Lhm-->children, a range of ...

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Searches Linking to this Article