DNA Damage Repair Alterations are Frequent in Prostatic Adenocarcinomas with Focal Pleomorphic Giant Cell Features.

07:00 EST 12th January 2019 | BioPortfolio

Summary of "DNA Damage Repair Alterations are Frequent in Prostatic Adenocarcinomas with Focal Pleomorphic Giant Cell Features."

Prostatic adenocarcinomas with focal pleomorphic giant cell features are a rare tumour subtype with abysmal clinical outcomes. More than one third of cases with this histology die within a year of the initial diagnosis of prostate cancer. Potential targeted therapies are desperately needed, however the molecular features of these tumours remain unknown.


Journal Details

This article was published in the following journal.

Name: Histopathology
ISSN: 1365-2559


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Medical and Biotech [MESH] Definitions

Repair of DNA DAMAGE by exchange of DNA between matching sequences, usually between the allelic DNA (ALLELES) of sister chromatids.

Disorders resulting from defective DNA REPAIR processes or the associated cellular responses to DNA DAMAGE.

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A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.

A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.

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