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Preparation of thermo/redox/pH-stimulative poly (N- isopropylacryamide- co-N, N'-dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors.

07:00 EST 16th January 2019 | BioPortfolio

Summary of "Preparation of thermo/redox/pH-stimulative poly (N- isopropylacryamide- co-N, N'-dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors."

Stimuli-sensitive drug delivery systems show beneficial features of both medical and pharmaceutical fields. In this paper, polymeric nanogel P (NIPAM-DMAEMA) (PND) with pH/redox/thermo-responsivenesses was synthesized by in situ polymerization of N-isopropylacryamide (NIPAM), N, N'-dimethylaminoethyl methacrylate (DMAEMA) for controlled release of doxorubicin hydrochloride (DOX). N, N'-bis (acryloyl) cystamine (BAC) and N, N'-methylene bisacrylamide (MBA) as the crosslinker, respectively. The structure, size and Zeta potential of PND-BAC and PND-MBA were further characterized. Moreover, after loading DOX, the encapsulation efficiency and the in vitro release behavior of PND-BAC/DOX and PND-MBA/DOX nanogels were discussed in details. Compared to PND-MBA NG, PND-BAC nanogels have the redox degradability due to the presence of crosslinker BAC. After loading DOX, the PND-BAC/DOX nanogel showed a higher encapsulation efficiency (81.6 ± 1.2) % and thermo- and pH-responsive as well as the redox-responsively in vitro release. These properties together with excellent environmentally sensitive properties, make PND-BAC became an attractive candidate for application in drug nanocarrier for targeted drug delivery of model pay loads. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Journal of biomedical materials research. Part A
ISSN: 1552-4965
Pages:

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