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Stimuli-sensitive drug delivery systems show beneficial features of both medical and pharmaceutical fields. In this paper, polymeric nanogel P (NIPAM-DMAEMA) (PND) with pH/redox/thermo-responsivenesses was synthesized by in situ polymerization of N-isopropylacryamide (NIPAM), N, N'-dimethylaminoethyl methacrylate (DMAEMA) for controlled release of doxorubicin hydrochloride (DOX). N, N'-bis (acryloyl) cystamine (BAC) and N, N'-methylene bisacrylamide (MBA) as the crosslinker, respectively. The structure, size and Zeta potential of PND-BAC and PND-MBA were further characterized. Moreover, after loading DOX, the encapsulation efficiency and the in vitro release behavior of PND-BAC/DOX and PND-MBA/DOX nanogels were discussed in details. Compared to PND-MBA NG, PND-BAC nanogels have the redox degradability due to the presence of crosslinker BAC. After loading DOX, the PND-BAC/DOX nanogel showed a higher encapsulation efficiency (81.6 ± 1.2) % and thermo- and pH-responsive as well as the redox-responsively in vitro release. These properties together with excellent environmentally sensitive properties, make PND-BAC became an attractive candidate for application in drug nanocarrier for targeted drug delivery of model pay loads. This article is protected by copyright. All rights reserved.
This article was published in the following journal.
Name: Journal of biomedical materials research. Part A
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Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.
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The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials.
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<!--LGfEGNT2Lhm-->Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. <!--LGfEGNT2Lhm-->Drug delivery technologies are <!--LGfEGNT2Lhm-->patent pr...
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...