Preparation of thermo/redox/pH-stimulative poly (N- isopropylacryamide- co-N, N'-dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors.

07:00 EST 16th January 2019 | BioPortfolio

Summary of "Preparation of thermo/redox/pH-stimulative poly (N- isopropylacryamide- co-N, N'-dimethylaminoethyl methacrylate) nanogels and their DOX release behaviors."

Stimuli-sensitive drug delivery systems show beneficial features of both medical and pharmaceutical fields. In this paper, polymeric nanogel P (NIPAM-DMAEMA) (PND) with pH/redox/thermo-responsivenesses was synthesized by in situ polymerization of N-isopropylacryamide (NIPAM), N, N'-dimethylaminoethyl methacrylate (DMAEMA) for controlled release of doxorubicin hydrochloride (DOX). N, N'-bis (acryloyl) cystamine (BAC) and N, N'-methylene bisacrylamide (MBA) as the crosslinker, respectively. The structure, size and Zeta potential of PND-BAC and PND-MBA were further characterized. Moreover, after loading DOX, the encapsulation efficiency and the in vitro release behavior of PND-BAC/DOX and PND-MBA/DOX nanogels were discussed in details. Compared to PND-MBA NG, PND-BAC nanogels have the redox degradability due to the presence of crosslinker BAC. After loading DOX, the PND-BAC/DOX nanogel showed a higher encapsulation efficiency (81.6 ± 1.2) % and thermo- and pH-responsive as well as the redox-responsively in vitro release. These properties together with excellent environmentally sensitive properties, make PND-BAC became an attractive candidate for application in drug nanocarrier for targeted drug delivery of model pay loads. This article is protected by copyright. All rights reserved.


Journal Details

This article was published in the following journal.

Name: Journal of biomedical materials research. Part A
ISSN: 1552-4965


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