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Li-Fraumeni syndrome presenting as cutaneous melanoma in a child: case report and review of literature.

07:00 EST 17th January 2019 | BioPortfolio

Summary of "Li-Fraumeni syndrome presenting as cutaneous melanoma in a child: case report and review of literature."

Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant inherited cancer predisposition syndrome associated with germline mutation of the TP53 tumor suppressor gene [1, 2]. It is traditionally characterized by early-onset of multiple primary tumors: sarcoma, breast cancer, brain tumor, leukemia, and adrenocortical carcinoma. [2] Classically, LFS is clinically diagnosed when a patient present with sarcoma diagnosed before age 45 years with a first-degree relative with any cancer before age 45 years and an additional first- or second-degree relative with any cancer before age 45 years or a sarcoma at any age. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
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