Extensive serological survey of multiple African non-human primate species reveals low prevalence of IgG antibodies to four Ebola virus species.

07:00 EST 18th January 2019 | BioPortfolio

Summary of "Extensive serological survey of multiple African non-human primate species reveals low prevalence of IgG antibodies to four Ebola virus species."

Bats are considered a reservoir species for Ebola viruses, but non-human primates (NHP) have represented a source of infection in several outbreaks in humans. Here we report serological screening of blood or fecal samples from monkeys (n=2,322) and apes (n=2,327). Thirty-six NHP species from Cameroon, Democratic Republic of Congo and Ivory Coast were tested with a sensitive and specific Luminex-based assay for IgG antibodies to four Ebolavirus species. Using the simultaneous presence of antibodies to NP and GP proteins to define positivity, we showed that specific Ebola virus antibodies are not widespread among NHP. Only one mustached monkey (Cercopithecus cephus) from Cameroon was positive for Sudan ebola virus. These observations support that NHP are most likely intermediate hosts for Ebola viruses. With the increasing frequency of Ebola outbreaks it is crucial to identify the animal reservoir and understand the ecology of Ebola viruses to inform disease control.


Journal Details

This article was published in the following journal.

Name: The Journal of infectious diseases
ISSN: 1537-6613


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