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Bats are considered a reservoir species for Ebola viruses, but non-human primates (NHP) have represented a source of infection in several outbreaks in humans. Here we report serological screening of blood or fecal samples from monkeys (n=2,322) and apes (n=2,327). Thirty-six NHP species from Cameroon, Democratic Republic of Congo and Ivory Coast were tested with a sensitive and specific Luminex-based assay for IgG antibodies to four Ebolavirus species. Using the simultaneous presence of antibodies to NP and GP proteins to define positivity, we showed that specific Ebola virus antibodies are not widespread among NHP. Only one mustached monkey (Cercopithecus cephus) from Cameroon was positive for Sudan ebola virus. These observations support that NHP are most likely intermediate hosts for Ebola viruses. With the increasing frequency of Ebola outbreaks it is crucial to identify the animal reservoir and understand the ecology of Ebola viruses to inform disease control.
This article was published in the following journal.
Name: The Journal of infectious diseases
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A strain of PRIMATE T-LYMPHOTROPIC VIRUS 2, closely related to the human HTLV-1 virus. The clinical, hematological, and histopathological characteristics of the disease in STLV-infected monkeys are very similar to those of human adult T-cell leukemia. Subgroups include the African green monkey subtype (STLV-I-AGM), for which the nucleotide sequence is 95% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1, and the Asian rhesus macaque subtype (STLV-I-MM), for which the nucleotide sequence is 90% homologous with that of HUMAN T-LYMPHOTROPIC VIRUS 1.
A genus of the family BUNYAVIRIDAE containing over 150 viruses, most of which are transmitted by mosquitoes or flies. They are arranged in groups defined by serological criteria, each now named for the original reference species (previously called serogroups). Many species have multiple serotypes or strains.
A species in the family DELTARETROVIRUS comprising strains of different host species but arising from the same geographic origin. They include HUMAN T-LYMPHOTROPIC VIRUS 1 and SIMIAN T-LYMPHOTROPIC VIRUS 1.
Strains of PRIMATE T-LYMPHOTROPIC VIRUS 3 isolated from diverse primate species.
Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.
An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals. Antibodies may be produc...
Marburg and Ebola Virus Infections
Ebola virus and Marburg virus are related viruses that cause hemorrhagic fevers — illnesses marked by severe bleeding (hemorrhage), organ failure and, in many cases, death. Both viruses are native to Africa, where sporadic outbreaks have occurred f...
Tropical Medicine is the study of diseases more commonly found in tropical regions than elsewhere. Examples of these diseases are malaria, yellow fever, Chagas disease, Dengue, Helminths, African trypanosomiasis, Leishmaniasis, Leprosy, Lymphatic filaria...