Physical Inaccessibility of a Resistant Starch Shifts Mouse Gut Microbiota to Butyrogenic Firmicutes.

07:00 EST 19th January 2019 | BioPortfolio

Summary of "Physical Inaccessibility of a Resistant Starch Shifts Mouse Gut Microbiota to Butyrogenic Firmicutes."

Resistant starch (RS) is utilized by Gram-negative Bacteroidetes through a starch utilization system (Sus), which requires physical attachment of the bacteria to the substrate. Gram-positive Firmicutes, which include butyrate-producers, utilize RS by other mechanisms, such as amylosomes and secreted amylases/glucoamylases. We previously showed that fabricated RS [alginate-based starch-entrapped microspheres (SM)] increased butyrate in in vitro human fecal fermentation and was slow fermenting. We hypothesized that in vivo SM would disfavor Bacteroidetes and promote Firmicutes, leading to increase in butyrate production.


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This article was published in the following journal.

Name: Molecular nutrition & food research
ISSN: 1613-4133
Pages: e1801012


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