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CD8+ T Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes.

07:00 EST 29th January 2019 | BioPortfolio

Summary of "CD8+ T Cell-Derived Tumor Necrosis Factor Can Induce Tissue Factor Expression on Monocytes."

Circulating CD8+ T cells and monocytes are activated during HIV infection and co-localize in the aortas of SIV-infected non-human primates. We hypothesized that CD8+ T cells could exert a pro-atherosclerotic effect via paracrine actions on monocytes. We find that T cell receptor (TCR)-stimulated CD8+ T cells induce monocytes to express tissue factor (TF), a potent activator of coagulation. Tumor necrosis factor (TNF) was both necessary and sufficient for this effect.

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Name: The Journal of infectious diseases
ISSN: 1537-6613
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Medical and Biotech [MESH] Definitions

A secreted tumor necrosis factor receptor family member that has specificity FAS LIGAND and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14. It plays a modulating role in tumor necrosis factor signaling pathway.

A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.

A member of the tumor necrosis factor receptor superfamily found on mature B-LYMPHOCYTES. It has specificity for B CELL ACTIVATING FACTOR and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

A tumor necrosis factor receptor subtype with specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15. It is found in tissues containing LYMPHOCYTES and may play a role in regulating lymphocyte homeostasis and APOPTOSIS. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

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