A Prebiotic Synthesis of Canonical Pyrimidine and Purine Ribonucleotides.

07:00 EST 30th January 2019 | BioPortfolio

Summary of "A Prebiotic Synthesis of Canonical Pyrimidine and Purine Ribonucleotides."

The "RNA first" model for the origin of life holds that RNA emerged spontaneously on early Earth and developed into life through its dual capabilities for genetics and catalysis. The model's central weakness is the difficulty of making its building blocks, in particular, the glycosidic bond joining nucleobases to ribose. Thus, the focus of much of the modern literature on the topic is directed toward solving this difficulty and includes elegant, though indirect, methods for making this bond. Here, we report that the glycosidic bond in canonical pyrimidine and purine ribonucleotides can be formed by direct coupling of cyclic carbohydrate phosphates with free nucleobases, all reported to be available by experimentally supported pathways that might have operated on early Earth.


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Name: Astrobiology
ISSN: 1557-8070


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Medical and Biotech [MESH] Definitions

Nucleotides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)

A purine or pyrimidine base bonded to DEOXYRIBOSE.

A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group.

Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)

The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.

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