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The "RNA first" model for the origin of life holds that RNA emerged spontaneously on early Earth and developed into life through its dual capabilities for genetics and catalysis. The model's central weakness is the difficulty of making its building blocks, in particular, the glycosidic bond joining nucleobases to ribose. Thus, the focus of much of the modern literature on the topic is directed toward solving this difficulty and includes elegant, though indirect, methods for making this bond. Here, we report that the glycosidic bond in canonical pyrimidine and purine ribonucleotides can be formed by direct coupling of cyclic carbohydrate phosphates with free nucleobases, all reported to be available by experimentally supported pathways that might have operated on early Earth.
This article was published in the following journal.
A mixture of sugar diphosphates is produced in reactions between small aldehyde phosphates catalysed by layered double hydroxide (LDH) clays under plausibly prebiotic conditions. A subset of these, pe...
Inborn errors of purine and pyrimidine metabolism are a diverse group of disorders with possible serious or life-threatening symptoms. They may be associated with neurological symptoms, renal stone di...
Under the aegis of the Pilot Scale Library Program of the NIH Roadmap Initiative, a new library of propan-1-amine containing aza acyclic nucleosides were designed and prepared, and we now report a div...
A main objective in the synthesis of prebiotic compounds is to remain consistent with reasonable geochemical scenarios, while avoiding concomitant formation of undesirable by-products. In this context...
Synthesis of [ N ] purine labelled cytokinine glycosides derived from zeatins and topolins containing a 9-β-D, 7-β-D-glucopyranosyl, or 9-β-D-ribofuranosyl group is described. These N -substituted ...
Concentrations of micronutrients (especially purine and pyrimidine) in cord blood, blood of mothers and infants and human milk is studied
OBJECTIVES: I. Determine the effects of aminoimidazole carboxamide riboside (AICAR) on hematologic manifestations of Lesch-Nyhan disease. II. Assess the behavioral and neurological bene...
This study will validate the sensitivity of a purine biosensor (SMARTChip) in detecting acute cerebral ischaemia in a group of patients undergoing elective carotid endarterectomy. The stud...
This study is designed to examine the shift in gut microbiota and their metabolism after consumption of a dietary supplement (prebiotic) by healthy participants. The investigators will pro...
The aim of the study is to confirm the effectiveness of chicory-derived prebiotic inulin-type fructans on bowel function in young children.
Nucleotides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)
A purine or pyrimidine base bonded to DEOXYRIBOSE.
A purine or pyrimidine base bonded to a DEOXYRIBOSE containing a bond to a phosphate group.
Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)
The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.