Dysregulation of SLC Transporters in Malaria-Infected Pregnant Mice.

07:00 EST 31st January 2019 | BioPortfolio

Summary of "Dysregulation of SLC Transporters in Malaria-Infected Pregnant Mice."

Malaria in pregnancy (MiP) alters the expression of ABC efflux transporters in maternal and fetal tissues, as well as the placenta. Malaria induces oxidative stress and pregnancy is associated with arginine deficiency. We hypothesized that reducing oxidative stress during MiP by L-arginine supplementation, a NO precursor, would attenuate transcriptional changes in a second superfamily of transporters, SLC transporters, and improve pregnancy outcomes.


Journal Details

This article was published in the following journal.

Name: Parasite immunology
ISSN: 1365-3024
Pages: e12614


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Medical and Biotech [MESH] Definitions

A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Malaria caused by PLASMODIUM VIVAX. This form of malaria is less severe than MALARIA, FALCIPARUM, but there is a higher probability for relapses to occur. Febrile paroxysms often occur every other day.

Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.

A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions.

Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.

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