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Exercise training offers possible non-pharmacological therapy for cardiovascular diseases including hypertension. High intensity intermittent exercise (HIIE) training has been shown to have as much or even more beneficial cardiovascular effect in patients with cardiovascular diseases than moderate intensity continuous exercise (CMIE) training. The aim of this study was to investigate the effects of the two types of training on cardiac remodeling of SHR (spontaneously hypertensive rats) induced by hypertension. Eight-week-old male SHRs and normotensive Wistar Kyoto rats (WKY) were divided into four groups: normotensive and hypertensive control (WKY and SHR-C), hypertensive trained with CMIE (SHR-T CMIE) or HIIE (SHR-T HIIE). After 8 weeks of training or inactivity, maximal running speed (MRS), arterial pressure and heart weight were all assessed. CMIE or HIIE protocols not only increased final MRS and left ventricular weight/body weight ratio, but also reduced mean arterial pressure (MAP) compared to sedentary group. Then, left ventricular tissue was enzymatically dissociated and isolated cardiomyocytes were used to highlight the changes induced by physical activity at morphological, mechanical and molecular levels. Both types of training induced restoration of transverse tubule regularity, decrease in spark site density and reduction in half-relaxation time of calcium transients. HIIE training, in particular, decreased spark amplitude and width, and increased cardiomyocyte contractility and the expression of SERCA and phospholamban phosphorylated on Serine 16.
This article was published in the following journal.
Name: Journal of applied physiology (Bethesda, Md. : 1985)
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A controlled learning environment that closely represents reality.
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Cardiovascular disease (CVD)
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