The individual functional connectome is unique and stable over months to years.

07:00 EST 2nd February 2019 | BioPortfolio

Summary of "The individual functional connectome is unique and stable over months to years."

Functional connectomes computed from fMRI provide a means to characterize individual differences in the patterns of BOLD synchronization across regions of the entire brain. Using four resting-state fMRI datasets with a wide range of ages, we show that individual differences of the functional connectome are stable across 3 months to 1-2 years (and even detectable at above-chance levels across 3 years). Medial frontal and frontoparietal networks appear to be both unique and stable, resulting in high ID rates, as did a combination of these two networks. We conduct analyses demonstrating that these results are not driven by head motion. We also show that edges contributing the most to a successful ID tend to connect nodes in the frontal and parietal cortices, while edges contributing the least tend to connect cross-hemispheric homologs. Our results demonstrate that the functional connectome is stable across years and that high ID rates are not an idiosyncratic aspect of a specific dataset, but rather reflect stable individual differences in the functional connectivity of the brain.


Journal Details

This article was published in the following journal.

Name: NeuroImage
ISSN: 1095-9572


DeepDyve research library

PubMed Articles [26415 Associated PubMed Articles listed on BioPortfolio]

EEG-based age-prediction models as stable and heritable indicators of brain maturational level in children and adolescents.

The human brain shows remarkable development of functional brain activity from childhood to adolescence. Here, we investigated whether electroencephalogram (EEG) recordings are suitable for predicting...

Individual and stable autoantibody repertoires in healthy individuals.

In the era towards precision medicine, we here present the individual specific autoantibody signatures of 193 healthy individuals. The self-reactive IgG signatures are stable over time in a way that e...

Developmental patterns of anger from infancy to middle childhood predict problem behaviors at age 8.

Anger is a central characteristic of negative affect and is relatively stable from infancy onward. Absolute levels of anger typically peak in early childhood and diminish as children become socialized...

High-resolution directed human connectomes and the Consensus Connectome Dynamics.

Here we show a method of directing the edges of the connectomes, prepared from HARDI datasets from the human brain. Before the present work, no high-definition directed braingraphs were published, bec...

The Emergent Connectome in Caenorhabditis elegans Embryogenesis.

The relatively new field of connectomics provides us with a unique window into nervous system function. In the model organism Caenorhabditis elegans, this promise is even greater due to the relatively...

Clinical Trials [7745 Associated Clinical Trials listed on BioPortfolio]

Impact of Brain Connectome and Personality on Cognitive Rehabilitation in Multiple Sclerosis

This study aims to apply baseline MRI and neuropsychological measures to predict patient responses to behavioral cognitive rehabilitation. Training will take place over 12 weeks, 1 hour pe...

Safety Study of CSL Limited's Influenza Virus Vaccine in the Paediatric Population Aged Between >= 6 Months to < 18 Years

A Phase IV, Open Label, Multi-Centre Study to Evaluate the Safety and Tolerability of CSL Limited's Influenza Virus Vaccine in a Paediatric Population Aged >= 6 Months to < 18 Years

Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder

Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional con...

Open-label Safety Study of Lubiprostone in Pediatric Subjects Aged ≥ 6 Years to < 18 Years With Functional Constipation

A study of the safety of Lubiprostone in pediatric subjects aged ≥ 6 Years to < 18 years diagnosed with Functional Constipation

SVR III: Brain Connectome and Neurodevelopmental Outcomes

Patients with hypoplastic left heart syndrome and other single right ventricle lesions who have undergone the Fontan procedure have a high risk of neurodevelopmental disorders that affect ...

Medical and Biotech [MESH] Definitions

Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.

Any observable response or action of a child from 24 months through 12 years of age. For neonates or children younger than 24 months, INFANT BEHAVIOR is available.

The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.

A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.

A species of RUBULAVIRUS associated particularly with acute laryngotracheitis (CROUP) in children aged 6 months to 3 years.

Quick Search


DeepDyve research library

Searches Linking to this Article