Connectomics: Arrested Development.

07:00 EST 4th February 2019 | BioPortfolio

Summary of "Connectomics: Arrested Development."

Connectomics, the reconstruction of neuronal wiring diagrams via electron microscopy, is bringing us closer to understanding how brains organize behavior. But high-resolution imaging of the brain can do more. A new study now provides insights into how neuronal circuits develop.


Journal Details

This article was published in the following journal.

Name: Current biology : CB
ISSN: 1879-0445
Pages: R90-R92


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Medical and Biotech [MESH] Definitions

A period of arrested growth or development in animals that is triggered by external conditions, such as length of day, extreme temperatures, or reduced food availability. It can occur at the embryonic, larval, pupal, or adult stage, depending on the species.

A localized arrested tooth development which appears to involve most commonly the anterior teeth, usually on one side of the midline, most often the maxillary central and lateral incisors. Roentgenographically, the teeth have a ghostlike appearance. Calcification and bits of prismatic enamel may be found in the pulp and the enamel is thin and absent in part. (Jablonski, Illustrated Dictionary of Dentistry, 1982)

A nonspecific term referring both to the pathologic finding of swelling of distal portions of axons in the brain and to disorders which feature this finding. Neuroaxonal dystrophy is seen in various genetic diseases, vitamin deficiencies, and aging. Infantile neuroaxonal dystrophy is an autosomal recessive disease characterized by arrested psychomotor development at 6 months to 2 years of age, ataxia, brain stem dysfunction, and quadriparesis. Juvenile and adult forms also occur. Pathologic findings include brain atrophy and widespread accumulation of axonal spheroids throughout the neuroaxis, peripheral nerves, and dental pulp. (From Davis & Robertson, Textbook of Neuropathology, 2nd ed, p927)

Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.

A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.

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