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Design, synthesis and evaluations of spiro-fused benzoxaborin derivatives as novel boron-containing compounds.

07:00 EST 5th February 2019 | BioPortfolio

Summary of "Design, synthesis and evaluations of spiro-fused benzoxaborin derivatives as novel boron-containing compounds."

Drug design using boron-containing heterocycles has attracted a great deal of attention because these compounds are believed to possess high biological activity. However, information on the synthetic methodology and pharmacokinetic profiling of boron-containing compounds is limited. In this study, we provide a new synthetic route for preparation of spiro-fused benzoxaborin derivatives and investigate their in vitro pharmacokinetic properties. Our efforts led to the successful construction of a chemical library of spiro-fused benzoxaborin derivatives with appropriate physicochemical and in vitro pharmacokinetic properties for oral drugs. These results indicate that the synthesized boron-containing compounds are therefore eligible for classification in a novel chemical library. This article is protected by copyright. All rights reserved.

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Name: Chemical biology & drug design
ISSN: 1747-0285
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