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TCRβ Repertoire of Memory T cell Reveals Potential Role for E.coli in the Pathogenesis of Primary Biliary Cholangitis.

07:00 EST 5th February 2019 | BioPortfolio

Summary of "TCRβ Repertoire of Memory T cell Reveals Potential Role for E.coli in the Pathogenesis of Primary Biliary Cholangitis."

Primary biliary cholangitis (PBC) is an organ-specific, T cell mediated autoimmune disease which is characterized by the breakdown of self-tolerance to the highly conserved pyruvate dehydrogenase complex, especially the pyruvate dehydrogenase E2 complex (PDC-E2). However, the molecular mechanism of breakdown of self-tolerance is still unclear.

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Name: Liver international : official journal of the International Association for the Study of the Liver
ISSN: 1478-3231
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