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Death Eaters Rely on Metabolic Signaling to Wield Anti-inflammatory Responses.

07:00 EST 5th February 2019 | BioPortfolio

Summary of "Death Eaters Rely on Metabolic Signaling to Wield Anti-inflammatory Responses."

Efferocytosis, the process by which dying or dead cells are removed by phagocytes, is essential to tissue homeostasis. However, how these "death eaters" or efferocytes coordinate phagocytosis with their immune function is incompletely understood. In this issue, Zhang et al. (2018) reveal how metabolic signaling drives the anti-inflammatory responses of efferocytes to promote wound healing.

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This article was published in the following journal.

Name: Cell metabolism
ISSN: 1932-7420
Pages: 234-236

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Medical and Biotech [MESH] Definitions

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

Intracellular signaling adaptor proteins that bind to the cytoplasmic death domain region found on DEATH DOMAIN RECEPTORS. Many of the proteins in this class take part in intracellular signaling from TUMOR NECROSIS FACTOR RECEPTORS.

A conserved protein interaction domain of the death domain superfamily that is structurally similar to the DEATH EFFECTOR DOMAIN and CASPASE RECRUITMENT DOMAIN. Death domains bind each other to form oligomers and occur on DEATH DOMAIN RECEPTORS, where they are required for APOPTOSIS signaling and non-apoptotic functions.

A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.

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