Track topics on Twitter Track topics that are important to you
Neuropeptides are peptide neuromodulators that are expressed by neurons and act on neural targets by activating neuropeptide receptors1. These receptors serve as therapeutic targets for the treatment of a number of pathophysiological conditions, including obesity, pain and addiction2-6. Major technological advances in the 1980s involving improved sensitivity of peptide purification methods and single neuron mRNA sequencing techniques have led to an explosion in the number of newly discovered neuropeptides7. However, to date, receptors for many of these neuropeptides remain largely unknown. In addition, currently there are a number of "orphan" G-protein-coupled receptors (GPCRs) for which endogenous ligands or function are yet to be identified8, 9.These "orphan" neuropeptides and GPCRs represent an untapped resource for the development of therapeutics to treat chronic diseases including drug abuse disorders, obesity and neuropathic pain. With this in mind much effort has been put towards deorphanizing these "orphan" peptides/GPCRs. Here, we summarize current insights into one such relationship: that between the neuropeptide PEN and the GPCR named GPR83. This intriguing system promises to deepen our current understanding of neuropeptide/GPCR systems, but also highlights the necessity for further technological advances in order to fully understand its complexity.
This article was published in the following journal.
Name: ACS chemical neuroscience
As a very abundant neuropeptide in the brain and widely distributed peptide hormone in the periphery, neuropeptide Y (NPY) appears to be a multisignaling key peptide. Together with peptide YY, pancrea...
The mechanisms underlying the relationship between life events and psychological distress are unclear. However, evidence of genetic involvement, including the neuropeptide S receptor gene (NPSR1), exi...
Previous studies have suggested that rapid reductions in depression-like behaviors are observed in response to sub-anesthetic-doses of ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist. Ne...
Understanding the mechanisms regulating feeding is crucial to unraveling the pathogenesis of obesity. The study primary explored the effects of orexin-A and neuropeptide Y (NPY) signaling in the hypot...
Insulin receptor (IR)-mediated signaling is involved in the regulation of pluripotent stem cells; however, its direct effects on regulating the maintenance of pluripotency and lineage development are ...
Gonadotropin-releasing hormone analogue (GnRH-a) "long protocol" is a protocol for pituitary down-regulation in IVF. However, it is common in clinic that some patients are hypersensitive t...
The distribution of stable (non-radioactive) isotopes in living organisms is increasingly studied, in particular the zinc (Zn), copper (Cu) and iron (Fe), not only in primitive organisms, ...
This study examines the role of the epidermal growth factor (EGF) receptor family and the EGF family of ligands in the regulation of non-myocytes isolated from the human heart.
The purpose of this study is to understand how dipeptidyl peptidase IV (DPP4) inhibition in diabetics affects hemodynamic parameters and sympathetic activation in the setting of increasing...
The neuropeptide oxytocin (OXT) has been identified as a key modulator of human social behavior and it has been recently shown that OXT also contributes to pair-bonding in men. However, it...
A signal transducing tumor necrosis factor receptor associated factor that mediates signaling from CD27 ANTIGENS; CD40 ANTIGENS; and the LYMPHOTOXIN BETA RECEPTOR. It is involved in regulation of NF-KAPPA B signaling.
PKC beta encodes two proteins (PKCB1 and PKCBII) generated by alternative splicing of C-terminal exons. It is widely distributed with wide-ranging roles in processes such as B-cell receptor regulation, oxidative stress-induced apoptosis, androgen receptor-dependent transcriptional regulation, insulin signaling, and endothelial cell proliferation.
A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signaling and activation of MITOGEN-ACTIVATED PROTEIN KINASES.
A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS). It contains an intrinsic protein-tyrosine kinase activity. When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation.
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of the Ki-1 antigen in hematopoietic malignancies make it clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...
An anesthesiologist (US English) or anaesthetist (British English) is a physician trained in anesthesia and perioperative medicine. Anesthesiologists are physicians who provide medical care to patients in a wide variety of (usually acute) situations. ...