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The search for new ways to diagnose diseases of different etiologies and their introduction into practical health care remains one of the priority areas of modern medicine. Among the known methods for the analysis of biological fluids, a special place is occupied by the methods of express diagnostics of various pathological conditions by markers found in the oral fluid. This article presents a critical review of the latest developments of domestic and foreign researchers (56 sources are analyzed) concerning both existing and widely used devices and those that are at the development stage. The prospects of using oral fluid as a diagnostic medium, as well as various methods for the rapid detction of markers of pathological conditions, are discussed. The main principles, advantages and disadvantages of immunochromatographic tests, electrochemical, microfluidic analysis, isothermal amplification, and devices based on smartphones for express diagnostics of various markers in oral fluid are presented.
This article was published in the following journal.
Name: Klinicheskaia laboratornaia diagnostika
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A class of natural contraceptive methods in which SEXUAL ABSTINENCE is practiced a few days before and after the estimated day of ovulation, during the fertile phase. Methods for determining the fertile period or OVULATION DETECTION are based on various physiological indicators, such as circulating hormones, changes in cervical mucus (CERVIX MUCUS), and the basal body temperature.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Miniaturized methods of liquid-liquid extraction.
The removal of a soluble component from a liquid mixture by contact with a second liquid, immiscible with the carrier liquid, in which the component is preferentially soluble. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Method to determine the occurrence of OVULATION by direct or indirect means. Indirect methods examine the effects of PROGESTERONE on cervical mucus (CERVIX MUCUS), or basal body temperature. Direct ovulation detection, generally used in fertility treatment, involves analyses of circulating hormones in blood and ULTRASONOGRAPHY.
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