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Lymphomas associated with chronic hepatitis C virus infection: A prospective multicentre cohort study from the Rete Ematologica Lombarda (REL) clinical network.

07:00 EST 6th February 2019 | BioPortfolio

Summary of "Lymphomas associated with chronic hepatitis C virus infection: A prospective multicentre cohort study from the Rete Ematologica Lombarda (REL) clinical network."

Chronic hepatitis C virus (HCV) infection is related with an increased risk of non-Hodgkin lymphomas (NHL). In indolent subtypes, regression of NHL was reported after HCV eradication with antiviral therapy (AT). In 2008, in Lombardy, a region of Northern Italy, the "Rete Ematologica Lombarda" (REL - Hematology Network of Lombardy - Lymphoma Workgroup) started a prospective multicentre observational cohort study on NHL associated with HCV infection, named "Registro Lombardo dei Linfomi HCV-positivi" ("Lombardy Registry of HCV-associated non-Hodgkin lymphomas"). 250 patients with a first diagnosis of NHL associated with HCV infection were enrolled: also in our cohort, diffuse large B cell lymphoma (DLBCL) and marginal zone lymphoma (MZL) are the two most frequent HCV-associated lymphomas. Two thirds of patients had HCV-positivity detection before
NHL:
overall, NHL were diagnosed after a median time of 11 years since HCV survey. Our data on eradication of HCV infection were collected prior the recent introduction of the Direct-Acting Antivirals (DAAs) therapy: 16 patients with indolent NHL, treated with interferon-based AT as first line anti-lymphoma therapy, because of the absence of criteria for an immediate conventional treatment for lymphoma, had an overall response rate of 90%. After a median follow-up of 7 years, the Overall Survival (OS) was significantly longer in indolent NHL treated with AT as first line (p=0.048): this confirms a favourable outcome in this subset. Liver toxicity was an important adverse event after a conventional treatment in 20% of all patients, in particular among DLBCL, in which it is more frequent the coexistence of a more advanced liver disease. Overall, HCV infection should be consider as an important co-pathology in the treatment of lymphomas and an interdisciplinary approach should be always considered, in particular to evaluate the presence of fibrosis or necroinflammatory liver disease.

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This article was published in the following journal.

Name: Hematological oncology
ISSN: 1099-1069
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Medical and Biotech [MESH] Definitions

A family of hepatotropic DNA viruses which contains double-stranded DNA genomes and causes hepatitis in humans and animals. There are two genera: AVIHEPADNAVIRUS and ORTHOHEPADNAVIRUS. Hepadnaviruses include HEPATITIS B VIRUS, duck hepatitis B virus (HEPATITIS B VIRUS, DUCK), heron hepatitis B virus, ground squirrel hepatitis virus, and woodchuck hepatitis B virus (HEPATITIS B VIRUS, WOODCHUCK).

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INFLAMMATION of the LIVER in humans caused by HEPATITIS DELTA VIRUS in conjunction with HEPATITIS B VIRUS and lasting six months or more.

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