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The objective of the present work aimed to explore the potential of bacterial cellulose (BC) for oral delivery of melatonin (MLT), a natural hormone that faces problems of low solubility and oral bioavailability. BC was hydrolyzed by sulfuric acid followed by the oxidation to prepare bacterial cellulose nanofiber suspension (BCNs). Melatonin-loaded bacterial cellulose nanofiber suspension (MLT-BCNs) was prepared by emulsion solvent evaporation method. The properties of freeze-dried BCs and MLT-BCNs were studied by Fluorescence microscopy (FM), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and thermo gravimetric (TG). The results indicated that the fibers in BCNs became short and thin compared with BC, MLT in MLT-BCNs was uniformly distributed, both BCNs and MLT-BCNs have good thermodynamic stability. The MLT-BCNs showed more rapid dissolution MLT rates compared to the commercially available MLT in SGF and SIF, the dissolution of the cumulative release rate was about 2.1 times of the commercially available MLT. The oral bioavailability of MLT-BCNs in rat was about 2.4 times higher than the commercially available MLT. Thus, MLT-BCNs could act as promising delivery with enhanced dissolution and bioavailability for MLT after oral administration.
This article was published in the following journal.
Name: International journal of pharmaceutics
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A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.
A family of G-protein-coupled receptors that are specific for and mediate the effects of MELATONIN. Activation of melatonin receptors has been associated with decreased intracellular CYCLIC AMP and increased hydrolysis of PHOSPHOINOSITIDES.
A melatonin receptor subtype primarily found expressed in the BRAIN and RETINA.
A melatonin receptor subtype that is primarily found in the HYPOTHALAMUS and in the KIDNEY.
A type of ion exchange chromatography using diethylaminoethyl cellulose (DEAE-CELLULOSE) as a positively charged resin. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
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