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Characterization of the first bla/ermB-carrying IncI1 plasmid from Latin America.

07:00 EST 4th February 2019 | BioPortfolio

Summary of "Characterization of the first bla/ermB-carrying IncI1 plasmid from Latin America."

Azithromycin represents a valid therapeutic option for gastrointestinal and systemic infections caused by multidrug resistant (MDR) diarrheagenic Escherichia coli, Shigella and Salmonella species. However, acquired macrolide resistance in these species has been increasingly described, mostly related to macrolide modifying enzymes encoded by mph- and erm-type genes. In this study, we characterized the first bla/ermB-carrying IncI1 plasmid from Latin America, which was detected in a MDR E. coli clinical isolate from Uruguay. Plasmid pUR-EC07 was a 105,836-bp IncI1 ST80 plasmid harboring blabla and ermB, and characterized by a backbone region of 92,554 bp, and a multi resistance region (MRR) of 13,282 bp, bounded by two directly-oriented IS26 elements, and inserted upstream of ResD. The MRR comprised two nested IS26-composite transposons (Tn6651 and Tn6652). Tn6651 included the ermBL-ermB operon flanked by two IS26 copies in opposite direction. Tn6652 included bla, with an upstream remnant of a Tn3-family transposon, and bla, located in a genetic context consisting of ISEcp1∆-IS10-bla-IS903D. To the best of our knowledge, pUR-EC07 represents the first IncI1 plasmid harboring ermB and bla described in Latin America. Given the wide dissemination of IncI-type plasmids in Salmonella enterica, an important concern is represented by the potential transfer of similar plasmids to strains resistant to ciprofloxacin, which would result in the loss of the three main therapeutic resources.

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Name: Plasmid
ISSN: 1095-9890
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