Bis(imido)vanadium(V)-Catalyzed 2+2+1 Coupling of Alkynes and Azobenzenes Giving Multi-Substituted Pyrroles.

07:00 EST 7th February 2019 | BioPortfolio

Summary of "Bis(imido)vanadium(V)-Catalyzed 2+2+1 Coupling of Alkynes and Azobenzenes Giving Multi-Substituted Pyrroles."

The combination of VCl(THF) and N,N-bis(trimethylsilyl)aniline (1a) is an efficient catalyst for [2+2+1] coupling reaction of alkynes and azobenzenes, giving multi-substituted pyrroles. A plausible reaction mecha-nism involves the generation of a mono(imido)vanadium(III) species as an initiation step, where 1a served as an imido source with concomitant release of 2 equiv of ClSiMe, followed by a subsequent reaction with azobenzene to form a catalytically active bis(imido)vanadium(V) species via N=N bond cleavage.


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This article was published in the following journal.

Name: Journal of the American Chemical Society
ISSN: 1520-5126


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Medical and Biotech [MESH] Definitions

Inorganic compounds that contain vanadium as an integral part of the molecule.

The reaction of two molecular entities via oxidation usually catalyzed by a transition metal compound and involving dioxygen as the oxidant.

A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.

Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.

The bestowing of tangible or intangible benefits, voluntarily and usually without expectation of anything in return. However, gift giving may be motivated by feelings of ALTRUISM or gratitude, by a sense of obligation, or by the hope of receiving something in return.

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