Continuous infusion vs. intermittent flushing of peripheral cannulas in neonates using a needleless connector: a prospective cohort study.

07:00 EST 7th February 2019 | BioPortfolio

Summary of "Continuous infusion vs. intermittent flushing of peripheral cannulas in neonates using a needleless connector: a prospective cohort study."

Objective To compare the duration of patency of peripheral intravenous cannulas between continuous infusion and intermittent flushing, while using a needleless intravenous connector in newborns admitted to the neonatal intensive care unit (NICU). Methods This is a prospective cohort study, including neonates admitted to the NICU who needed a peripheral intravenous cannula for intermittent administration of intravenous medication. In the first period, neonates received continuous peripheral infusion with NaCl 0.9% at 0.2 mL/h. In the second period, cannulas were flushed with NaCl 0.9% (0.5 mL before and 0.3 mL after the administration of intravenous medication). Results A total of 113 neonates (210 cannulas) were included in the study, 55 received continuous peripheral infusion and 58 received intermittent flushing. Intermittent flushing resulted in a significantly longer duration of cannula patency compared to continuous infusion (geometric mean 47.1 vs. 35.4 h, P=0.041). The incidence of extravasation was higher with continuous infusion (68.9% vs. 43.2%; P=0.001), while occlusion was more common with intermittent flushing (28.4% vs. 6.6%; P=0.002). Conclusions Intermittent flushing of peripheral cannulas (using needleless intravenous connectors) results in longer cannula patency compared to continuous infusion, in neonates requiring only intermittent administration of medication.


Journal Details

This article was published in the following journal.

Name: Journal of perinatal medicine
ISSN: 1619-3997


DeepDyve research library

PubMed Articles [6153 Associated PubMed Articles listed on BioPortfolio]

Development and external evaluation of a population pharmacokinetic model for continuous and intermittent administration of vancomycin in neonates and infants using prospectively collected data.

Vancomycin is commonly used for nosocomial bacterial pathogens causing late-onset septicaemia in preterm infants. We prospectively collected pharmacokinetic data aiming to describe pharmacokinetics an...

Is continuous better than intermittent control of tracheal cuff pressure? A meta-analysis.

To compare and evaluate the efficacy and safety of continuous and intermittent control of P .

Clinical observation of continuous and intermittent application of lamivudine or entecavir resistance mutations in patients with chronic hepatitis B.

To observe continuous and intermittent application of lamivudine or entecavir resistance mutations in patients with chronic hepatitis B. Data of patients with active stage of chronic hepatitis B over...

Complications During Continuous Renal Replacement Therapy in Critically Ill Neonates.

Background/ Aims: Owing to practical and technical developments, continuous renal replacement therapy (CRRT) has been administered even in critically ill neonates. In this study, the complications in ...

Peripheral Intravenous Access: Applying Infusion Therapy Standards of Practice to Improve Patient Safety.

The most common invasive procedure performed in the hospital setting worldwide is the insertion of a peripheral intravenous catheter. Although use of peripheral intravenous access is common, its prese...

Clinical Trials [7911 Associated Clinical Trials listed on BioPortfolio]

RCT of Continuous Versus Intermittent Infusion of Vancomycin in Neonates

Babies aged < 28 days with a suspected infection requiring treatment with vancomycin will be recruited. They will be randomised to receive vancomycin as an intermittent infusion (over 1 ho...

Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients

This is a randomized, controlled multicenter clinical trial. The purpose of this study is to compare the continuous infusion of vancomycin with intermittent infusion regarding the effectiv...

Randomized Comparison of Continuous and Intermittent Heparin Infusion During Catheter Ablation of Atrial Fibrillation

Optimal anticoagulation using heparin with close attention to maintain therapeutic dosing during the procedure is important. Randomized comparison of continuous and intermittent heparin i...

Randomized Trial of Continuous Versus Intermittent Cefotaxime Infusion on ICU.

This study evaluates target attainment after either intermittent intravenous bolus or intravenous continuous infusion of cefotaxime in critically ill patients. Critically ill patients will...

Continuous Versus Intermittent Bolus Infusion of Paravertebral Blocks for Thoracic Surgery

The researchers are trying to determine pain medication consumption in the first 24 hours after surgery in patients given the standard continuous infusion of local anesthetic versus patien...

Medical and Biotech [MESH] Definitions

Alcohol analog of NICOTINIC ACID which is a direct-acting peripheral vasodilator that causes flushing and may decrease blood pressure. It is used in vasospasm and threatened GANGRENE.

Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.

Care over an extended period, usually for a chronic condition or disability, requiring periodic, intermittent, or continuous care.

A schedule prescribing when the subject is to be reinforced or rewarded in terms of temporal interval in psychological experiments. The schedule may be continuous or intermittent.

Hospital units providing continuous surveillance and care to acutely ill infants and children. Neonates are excluded since INTENSIVE CARE UNITS, NEONATAL is available.

Quick Search


DeepDyve research library

Relevant Topics

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Searches Linking to this Article