Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta.

07:00 EST 7th February 2019 | BioPortfolio

Summary of "Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta."

Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC value of 0.17 μM and rapidly induced cell death at a concentration of 2 μM. Minnamide A induced the copper-mediated accumulation of reactive oxygen species.


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Name: Organic letters
ISSN: 1523-7052


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