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Plant viral diseases cause tremendous decreases in yield and quality. Natural product gramine (1) and its structure simple analogues 2-35 were synthesized from indoles, amines and aldehydes in one step. The antiviral activities of these alkaloids were evaluated for the first time. Most of these compounds displayed higher antiviral activities than commercial antiviral agent ribavirin. Compounds 22, 30 and 31 exhibited significantly higher antiviral activities than ningnanmycin (perhaps the most successful registered antiplant viral agent), emerging as new lead compounds for antiviral research. In vitro capsid protein (CP) assembly and Tobacco Mosaic Virus (TMV) rod assembly inhibition determinations indicated that these compounds likely exerted their virus inhibition by crosslinking TMV CP and interfered with virus assembly. Further fungicidal activity tests against 14 kinds of phytopathogenic fungi revealed that gramine analogues displayed broad-spectrum fungicidal activities. Although gramine has been reported to have influence on germination and development of Erysiphe graminis, all of the compounds showed no inhibitory effect against Blum eria graminis f. sp.tritici on wheat in our test. Some of these compounds also exhibited certain insecticidal activities.
This article was published in the following journal.
Name: Journal of agricultural and food chemistry
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The systematic search and discovery of natural substances which may have potential commercial applications.
The process of finding chemicals for potential therapeutic use.
Experience-based techniques for problem-solving, learning, and discovery that find a solution which is not guaranteed to be optimal, but sufficient for a given set of goals.
Management activities required to maintain research data to ensure that they are fit for contemporary use and available for discovery and reuse.
A process that searches for hidden and important connections among information embedded in published literature.
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...