Synthesis and fabrication of surface-active microparticles using membrane emulsion technique and rapid conjugation of model protein via strain-promoted azide-alkyne click chemistry in physiological conditions.

07:00 EST 7th February 2019 | BioPortfolio

Summary of "Synthesis and fabrication of surface-active microparticles using membrane emulsion technique and rapid conjugation of model protein via strain-promoted azide-alkyne click chemistry in physiological conditions."

The rapid surface immobilisation of protein on monodispersed polyester microcarriers is reported. A model protein, functionalised with a dibenzocyclooctyne core, immobilises on the surface of azide-terminal polycaprolactone microcarriers within 10 minutes compared to 12 hours for other conjugation techniques and is conducted in physiological conditions and in the absence of coupling reagents.


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This article was published in the following journal.

Name: Bioconjugate chemistry
ISSN: 1520-4812


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