Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity.

07:00 EST 7th February 2019 | BioPortfolio

Summary of "Postnatal undernutrition alters adult female mouse cardiac structure and function leading to limited exercise capacity."

Impaired growth during fetal life can reprogramme heart development and increase the risk for long-term cardiovascular dysfunction. It is uncertain if the developmental window during which the heart is vulnerable to reprogramming as a result of inadequate nutrition extends into the postnatal period. We found that adult female mice that had been undernourished only from birth to 3 wk of age had disproportionately smaller hearts compared to males with thinner ventricle walls and more mononucleated cardiomyocytes. In females, but not males, cardiac diastolic function, and heart rate responsiveness to adrenergic stimulation were limited and maximal exercise capacity was compromised. These data suggest that the developmental window during which the heart is vulnerable to reprogramming by inadequacies in nutrient intake may extend into postnatal life and such individuals could be at increased risk for a cardiac event as a result of strenuous exercise.


Journal Details

This article was published in the following journal.

Name: The Journal of physiology
ISSN: 1469-7793


DeepDyve research library

PubMed Articles [20933 Associated PubMed Articles listed on BioPortfolio]

Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart.

WDR1 is a major cofactor of the actin depolymerizing factor (ADF)/cofilin, accelerating ADF/cofilin-mediated actin disassembly. We had previously showed that WDR1-mediated actin dynamics is required f...

Developmental and sex differences in cardiac tolerance to ischemia/reperfusion injury: the role of mitochondria.

Age and sex play essential role in the cardiac tolerance to ischemia/reperfusion (I/R) injury: cardiac resistance significantly decreases during postnatal maturation and female heart is more tolerant ...

Transient inhibition of neddylation at neonatal stage evokes reversible cardiomyopathy and predisposes the heart to isoproterenol-induced heart failure.

Alterations in perinatal conditions (such as preterm birth) is linked to adult health and disease, in particular, the cardiovascular system. Neddylation, a novel post-translational modification throug...

Maternal protein restriction during perinatal life affects lung mechanics and the surfactant system during early postnatal life in female rats.

Limited information is available on how fetal growth retardation (FGR) affects the lung in the neonatal period in males and females. This led us to test the hypothesis that FGR alters lung mechanics a...

Prenatal exposure to testosterone induces cardiac hypertrophy in adult female rats through enhanced Pkcδ expression in cardiac myocytes.

High circulating androgen in women with polycystic ovary syndrome (PCOS) may increase the risk of cardiovascular disease in offspring. The aim of the present study is to investigate whether maternal a...

Clinical Trials [9226 Associated Clinical Trials listed on BioPortfolio]

Analysis of the Impact of the Undernutrition on the Cerebral Infarct in Thrombolized Patients

Many clinical trials show that 30 to 50 % of the hospitalized patients are undernourished in various degrees. This prevalence didn't change since 15-20 years The fact is that the present u...

Evaluation of the SARC-F Score as a Screening Tool for Undernutrition in a Geriatric Population

To study the relationship between sarcopenia and undernutrition in adult patients over 70 years of age, and at the same time to define a threshold value for the predictive SARC-F score of ...

Supplementation With Nutrients Modulating IGF-1 and Cytokines in Elderly People at Risk of Undernutrition

The purpose of this study was to determine the improvement in nutritional status, especially in the level of insulin-like growth factor-1 (IGF-1) and its relationship with changes in the c...

Undernutrition Screening by Ultrasound Measure in Patients Handled by Mechanical Ventilation in Intensive Care

Undernutrition is a major factor of occurrence of complications and mortality in patients managed in intensive care. Early screening and follow-up are recommended in patients with undernut...

Follow-up of Malnutrition Screening in USINV

This aim of the study is to set up a procedure for screening for undernutrition in the neurovascular intensive care unit. This screening procedure follows a specific work concerning undern...

Medical and Biotech [MESH] Definitions

Visualization of the heart structure and cardiac blood flow for diagnostic evaluation or to guide cardiac procedures via techniques including ENDOSCOPY (cardiac endoscopy, sometimes refered to as cardioscopy), RADIONUCLIDE IMAGING; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY; or ULTRASONOGRAPHY.

Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).

MYCOBACTERIUM infections of the female reproductive tract (GENITALIA, FEMALE).

Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).

Pathological processes of the female URINARY TRACT and the reproductive system (GENITALIA, FEMALE).

Quick Search


DeepDyve research library

Relevant Topics

Cardiology is a specialty of internal medicine.  Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...

Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Searches Linking to this Article