Advertisement

Topics

The free radical theory of frailty: Mechanisms and opportunities for interventions to promote successful aging.

07:00 EST 5th February 2019 | BioPortfolio

Summary of "The free radical theory of frailty: Mechanisms and opportunities for interventions to promote successful aging."

The free radical theory of ageing has provided a framework of research into ageing based on Harman's idea that ageing was caused by damage produced by free radicals. However, several experiments have cast doubts on the general validity of the theory. The postulation of the free radical theory of frailty came from two basic facts: first that radicals not only act as damaging molecules, but also as signals to control cell function and second that on many occasions oxidative damage does not correlate with chronological but rather with unsuccessful ageing. Frailty is a geriatric concept by which an older person shows a lack of the feeling of wellbeing, unintentional weight loss, a relatively low grip strength, lowering the speed of walking, and difficulties to stand. If left untreated, frailty progresses to disability. Many interventions that prevent oxidative damage to cells do not affect longevity but have a clear effect on the prevention of frailty and its transition to disability. Clinical trials have shown that exercise programmes do not promote longevity but delay the onset of frailty. Experiments and mechanisms to support this idea are described.

Affiliation

Journal Details

This article was published in the following journal.

Name: Free radical biology & medicine
ISSN: 1873-4596
Pages:

Links

DeepDyve research library

PubMed Articles [21948 Associated PubMed Articles listed on BioPortfolio]

Review of Interventions for the Frailty Syndrome and the Role of Metformin as a Potential Pharmacologic Agent for Frailty Prevention.

Frailty is a syndrome of vulnerability and physical decline with aging that increases risk for disability, hospitalizations, and death. To date, interventions for frailty have primarily focused on e...

Rodent models of frailty and their application in preclinical research.

In clinical medicine, the concept of frailty is viewed as a state of high vulnerability to adverse health outcomes in people of the same age. Frailty is an important challenge because the loss of phys...

Frailty as a predictor of complications after radical cystectomy: A prospective study of various preoperative assessments.

Frailty has been correlated with worse postoperative outcomes. Prospective studies examining frailty and bladder cancer are lacking. We aimed to determine whether a prospective frailty assessment or t...

Modulation of frailty syndrome by diet: a review of evidence from mouse studies.

Frailty is a progressive, aging-related syndrome of unknown etiology characterized by increased susceptibility and decreased resilience to external stressors. Understanding underlying mechanisms and i...

Relationship between clinical outcomes and Dutch frailty score among elderly patients who underwent surgery for hip fracture.

Frailty is a geriatric condition that is associated with an increased risk of mortality and functional decline. To date, mainly the Groningen Frailty Indicator (GFI) and Hospital Safety Management (Ve...

Clinical Trials [8810 Associated Clinical Trials listed on BioPortfolio]

Individual and Environmental Mechanisms of PA Change

The focus of this study is to determine the mechanisms that underlie Physical Activity behavior change. We have 2 primary objectives. One, to test the effectiveness of brief, practical int...

Metformin for Preventing Frailty in High-risk Older Adults

Frailty is a geriatric syndrome which leads to poor health outcomes in older adults, such as falls, disability, hospitalization, institutionalization, and death. Due to the dramatic growth...

Exercise to Treat Frailty in Kidney Transplant Candidates

Frailty is a condition characterized by slowness, weakness, low physical activity, wasting, and exhaustion. Frailty increases the risk for adverse outcomes following transplant such as inc...

Frailty Rehabilitation

Frailty is an important clinical state that contributes to falls, hospitalization, institutionalization and death. When an individual simultaneously has many health problems, a frailty "ti...

The Utility of Focused Frailty Interventions on Patients With Advanced Heart Failure

The Researchers are doing this study to find out if the cardiac rehabilitation program can improve measurements of frailty and improve independence, functional abilities, and feelings abou...

Medical and Biotech [MESH] Definitions

A technique for detecting short-lived reactive FREE RADICALS in biological systems by providing a nitrone or nitrose compound for an addition reaction to occur which produces an ELECTRON SPIN RESONANCE SPECTROSCOPY-detectable aminoxyl radical. In spin trapping, the compound trapping the radical is called the spin trap and the addition product of the radical is identified as the spin adduct. (Free Rad Res Comm 1990;9(3-6):163)

Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.

Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.

An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.

The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topic

Clinical Approvals
Clinical trials are a set of procedures in medical research conducted to allow safety (or more specifically, information about adverse drug reactions and adverse effects of other treatments) and efficacy data to be collected for health interventions (e.g...


Searches Linking to this Article